Health Debate: The Moral Panic Over Ozempic Misses the Point

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The Moral Panic Over Ozempic Misses the Point​


The media has made the drugs about body politics and our obsession with thinness. That’s the wrong story.​

By Rachael Bedard
Illustration: Lucy Jones
d6a1c4e2bae808aec6a22a179e8835d6d8-ozempic.rhorizontal.w1100.jpg

This article was featured in One Great Story, New York’s reading recommendation newsletter. Sign up here to get it nightly.

In 2002, the FDA approved Suboxone, a new medication to treat opioid use disorder. Suboxone is a compound of two drugs that decreases one’s cravings for opioids while blocking their effects. It is safer and less cumbersome than methadone, which requires daily or weekly visits to a clinic, and more effective than any abstinence-based treatment, which requires people to withstand cravings and suppress physical discomfort. In clinical trials, Suboxone was shown to help opioid users avoid jail time and to decrease their mortality by over 50 percent. “You’d think that anything that can help save a heroin addict’s life would be seen as a good thing,” the writer and academic Michael Clune wrote in 2014, a year that marked an inflection point in an epidemic of fentanyl-related deaths. “So why, then, when I touted Suboxone at an Narcotics Anonymous meeting with a bunch of regulars did they look at me as if I’d gone insane?”

Clune has a history of heroin addiction (he wrote, to my mind, one of the great heroin-addiction memoirs) but successfully wrestled his demons into submission through a stay in rehab, diligent attendance at Narcotics Anonymous, exercise, and an enigmatic, epiphanic experience of grace. He knows how lucky he is to have overcome his addiction through struggle and also knows how rarely his strategy works for others. But when he proposed to friends in the recovery community that Suboxone is a worthy tool, they were upset; they were skeptical of a fix so expedient, so simple, so biological. “That’s like telling someone that smoking crack will get their mind off booze,” one NA longtimer argued. “Your recovery is based on a spiritual awakening,” another explained to Clune angrily. To this friend, Suboxone — a magic pill that changes the brain — would foreclose a person’s chance of personal transformation.

I thought of Clune’s essay often as I followed last year’s media coverage of Ozempic, Wegovy, Mounjaro, and other new medications that cause weight loss (from here, I’ll just use “Ozempic” as a shorthand for the whole class). Like Suboxone, Ozempic is a startlingly effective pharmacological intervention for a problem — obesity — that is common, stigmatized, complicated, and deadly. Helping people lose weight is only one of its benefits. At the homeless clinic in Brooklyn where I work as a doctor, most of the patients suffer from long-standing, intersecting chronic illnesses that doom them to trajectories of debility and decline: uncontrolled diabetes that hastens kidney disease, kidney disease that worsens high blood pressure, high blood pressure that increases the risk of heart attacks and strokes. Until recently, this was a Gordian knot that was impossible to cut with medication alone; my patients routinely take a full pharmacopeia a day and yet their conditions progress.

But now, suddenly, I’m hopeful. Ozempic seems to be something of a miracle. It’s a very effective treatment for diabetes as well as high blood pressure, heart failure, and kidney disease.

New evidence suggests that it improves depression and reduces suicidality, and it also seems, unexpectedly, to reduce non-food-related addictive behaviors, like gambling. Studies are underway to see if it prevents cancer and Alzheimer’s disease.

There’s much more to learn, and we don’t understand how these drugs work so well. It isn’t just a matter of shedding fat and getting glucose under control; as a side effect of Ozempic’s potency, we’re gaining new insight into the relationship between mind and metabolism.


2023 was year one of the Ozempic Revolution, and the revolution has been televised, TikTok’d, Instagrammed, tweeted, and written about everywhere. Some of the coverage has been about the medications’ startling efficacy, but most of the big juicy deep dives into what the medications are, what they do, and what they mean have focused not on their astounding clinical effects but on what Ozempic reveals about our morals and values, about identity and our obsession with thinness. In magazine features, opinion pieces, and essays across prestige media, the medicines have been written about almost exclusively as a double-edged sword, a reflection of our vanities and insecurities, or an expensive, overhyped pharmaceutical ploy. The drugs have been treated as an existential threat to the still-new body-positivity movement or a shortcut primarily for the rich and already thin. Stories that have considered what the drugs could mean for the not-rich offer dour arguments that Ozempic will exacerbate health inequalities or break the health-care bank. Having emerged at the same time as AI assistants like ChatGPT, these drugs have been assessed during a broad reckoning with what it means to take the effort out of hard things. The overarching implication is that even if the medicines are as amazing as the studies claim, we can’t afford them, and even if we can afford them, we probably want them for the wrong reasons.

The media class has turned Ozempic into a mirror for our cultural shortcomings, but when we stare at it primarily in search of our reflection, we miss the chance to recognize its true significance.

In October, the sociologist and writer Tressie McMillan Cottom wrote an essay for the New York Times “Opinion” section in which she says, “If GLP-1 drugs only treated diabetes and did not promote weight loss, they would still be medically groundbreaking. But Ozempic, Wegovy and Mounjaro probably would not have social media hashtags. These drugs are blockbusters because they promise to solve a medical problem that is also a cultural problem — how to cure the moral crisis of fat bodies that refuse to get and stay thin.” In her piece, McMillan Cottom makes mention of diabetes and the murky category of prediabetes, but her discussion dwells primarily on what she sees as the drugs’ cultural implications: the way they function as “a shorthand for our coded language of shame, stigma, status and bias around fatness.” McMillan Cottom’s distinction between the “medical problem” and “cultural problem” of obesity is a common theme of the Ozempic coverage; most pieces offer an obligatory nod toward the drug’s therapeutic effects but then are most eager to discuss its implications for body politics.
The first wave of Ozempic coverage was largely about celebrities — were Julia Fox and Kim Kardashian taking it? — which set the themes that would define the Ozempic discourse that followed: vanity, beauty standards, and class. In February 2023, in this magazine, Matthew Schneier wrote a cover story in which he profiled actresses, artists, and fashion employees who were taking the medication to shed ten pounds. “Weren’t we supposed to have moved on from this?” Schneier wondered — “this” referring to the tale as old as time of women chasing trends to look more svelte.

In March, The New Yorker writer Jia Tolentino ordered bootleg Ozempic through a pill-mill-type service to prove its ready availability to anyone with a credit card.

Once the drug seemed to be everywhere, some writers struggled with whether taking it might mean abandoning their commitment to body positivity. In the Cut, Samhita Mukhopadhyay wrote a vulnerable essay about her reluctance to take Mounjaro. “I was too ashamed to say it out loud,” she wrote, “but the drug was working, and I wasn’t sure how I felt about it.” In August, Emma Specter wrote in Vogue about how she would have wanted the drug five years ago but was now at a more radical place of self-acceptance. “What would we do — who would we be — if we let our bodies and lives exist more or less as they are, without looking to drugs like Ozempic to free us from the eternal trap of bodily perfection?” Specter asked.

The cultural and emotional implications of the drug’s weight-loss effects, especially shame, became a recurrent theme. In the New York Times, Aaron Carroll, a physician, wrote about overcoming his own resistance to trying the medicine for weight loss, and in the Washington Post, Ruth Marcus published a long reported essay about her initially ambivalent experience taking Ozempic in which she confessed, “As my weight loss began to show … I realized that I had internalized the sense that being heavy was a failing for which I was personally responsible.”

In early summer, the New York Times published a story with the headline “New Obesity Drugs Come With a Side Effect of Shaming” and then reprised the topic during the holidays: “Plates are full. Families may be quick to judge. What happens when weight-loss drugs collide with Thanksgiving?” As the year drew to a close, Ozempic’s implications for “the eternal trap of bodily perfection” remained a focus: In late December, Jennifer Weiner wrote in the New York Times about Oprah Winfrey’s choice to take one of these medications, claiming that Winfrey’s public weight struggles had reinforced the idea that “every woman’s body is a battleground … and that thinness is a woman’s true life’s work.”

Meanwhile, new information about Ozempic was emerging in the medical literature. By December, the results of the SELECT trial had been announced: It turns out that Ozempic reduces heart attacks, strokes, and cardiovascular mortality for people who are overweight, even if they don’t have diabetes. We also had initial results from the FLOW trial, suggesting that Ozempic prevents diabetics with kidney disease from needing dialysis. Forty percent of Americans are obese, and 12 percent have diabetes. These results suggest that Ozempic might change the shape and length of their lives more than anything we’ve previously had to offer.

In my job, I regularly encounter the type of story that I wish we were telling about Ozempic. Recently, I met a woman I’ll call Arlene. Arlene has bad diabetes and is about 80 pounds overweight. Diabetes is a hard condition to manage; injecting insulin causes weight gain, so treating it often causes a person’s obesity to worsen. Arlene lives in a shelter where she eats what the shelter serves her, which is basically shit, and she’s in a wheelchair, which prevents her from exercising. We had a hard, tearful visit because a lot is going wrong in her life and she’s under significant stress. But one thing was going well. A few weeks before I met her, a specialist had started Arlene on Ozempic.

In four weeks, Arlene had lost almost ten pounds. Her blood sugar was already in much better control, and she thought her back pain had improved. Arlene used the word “miracle” to describe the effects; the medication was the first thing in a long time to make her feel hopeful.

People like Arlene remain curiously absent from the Ozempic discourse, and they don’t seem to be anyone’s imagined reader, either. Not one of the first-person essays and opinion pieces that I read last year was written by a person with serious chronic illness. Never hearing this perspective means we don’t actually understand the experiences of the people who most stand to gain from Ozempic’s arrival. All medical problems are cultural problems — all illnesses exacerbate structural inequalities and provoke identity questions and elicit stigma — but by now, the cultural implications of struggling with one’s weight are so well covered that they have spawned a kind of genre writing. In all of the stories I’ve mentioned — and in similar coverage in The Atlantic, Slate, and elsewhere — “Ozempic” plays the same role that “Weight Watchers” or “diet culture” or “plastic surgery” have played in stories written over the past 30 years. Despite everything we now know about Ozempic’s radical therapeutic potential, we’re still calling it a “weight-loss drug,” which allows us to keep it in a zone of moral ambivalence and interpret it using familiar conventions.

Conversely, we don’t have popular, well-developed narratives about the chronic diseases that result from glucose derangement and excess fat tissue, which disproportionately debilitate people who are poor and racialized. We have the cultural elite’s obsession with Susan Sontag’s Illness As Metaphor, we have cancer memoirs, and we have an emerging post-pandemic literature about the vagaries and difficulties of living with long COVID. We have no canon of great writing about struggling with cirrhosis or the decision to get a diabetic amputation. “There aren’t breathless profiles of a pharmaceutical drug because it will help a diabetic manage her blood glucose level,” McMillan Cottom observed in her essay. She’s right. America’s silent majority of chronic-disease sufferers — dying prematurely, disabled, or on dialysis — desperately need this drug. For them, taking this medication and losing weight isn’t a question of succumbing to vanity or vanquishing one’s inner critic.

Elite media discourse around Ozempic can meaningfully influence public opinion and health-care policy. Right now, the most urgent concern about Ozempic is the fact that everyone who needs and wants it cannot get it.

Recently, the state of North Carolina had to rescind its policy of paying for the drugs for people who do not have diabetes — in other words, people prescribed the medications primarily for weight loss — because it could no longer afford the ballooning costs. The drugs can cost up to $16,000 a year (depending on the one prescribed), an out-of-pocket cost few people can bear.

So far, the public discussion of Ozempic’s daunting economics have been consistently fatalistic. At the end of the summer, the columnist Megan McArdle and the physician Leana Wen wrote op-eds in the Washington Post within two months of each other saying the cost benefit for the drugs may not pencil out. Nearly every story I’ve read has used the current access challenges as reason to doubt the drug’s miracle status: If it’s only going to be available to the luckiest few, what makes it any better than Botox? Jia Tolentino, in The New Yorker, wrote, “It is possible to imagine a different universe in which the discovery of semaglutide was an unalloyed good … In the actual universe that we inhabit, the people who most need semaglutide often struggle to get it, and its arrival seems to have prompted less a public consideration of what it means to be fat than a renewed fixation on being thin.”

As long as we talk about these medications primarily as “weight-loss drugs” — as medications that have prompted “a renewed fixation on being thin” — insurance companies and policymakers will remain incentivized to treat them as a luxury good. We’ll never ask the questions that need to be asked: If such a large percentage of the country wants Ozempic, and if we now have good-quality evidence that it helps with a variety of serious conditions beyond diabetes, what is our cutoff for determining who truly needs it? And how do we make it available to them? Price is not an inherent feature of most pharmaceuticals.

Ozempic already costs less in other countries, and in the U.S., the president recently took the extraordinary step of lowering drug costs for some of the most commonly prescribed medications by using his executive authority. Ozempic presents a radical opportunity to change the chronic-disease landscape in this country. It may require radical policy to make it accessible, and what that policy looks like is the conversation I want to have.

In a culture where we so powerfully associate wealth, beauty, and thinness, I wonder if we simply can’t envision recategorizing a medicine like Ozempic, something rich people want, as an intervention for the non-rich. We are comparing Ozempic to the wrong precedents — fen-phen in the 1990s gets mentioned a lot; McMillan Cottom compares the hype it’s received to Botox and Viagra — and missing the analogies that would be most helpful.

In a hopeful end-of-year story in The New Yorker, Dhruv Khullar compares Ozempic to COVID therapies and the COVID vaccine: interventions that made an overwhelming, seemingly intractable public-health crisis suddenly much less so.

The comparison is a useful one, because it also points toward how Ozempic’s initial access issues do not mean that it cannot, ultimately, play a powerful role in reducing health disparities. Initial coverage of the COVID vaccine focused a lot on the equity concerns surrounding who would get it first. And yet, because the vaccine was disproportionately beneficial to the populations most vulnerable to serious COVID outcomes, the poor, sick, and elderly were ultimately most helped by it, even if they got it two months later than they should have.

Suboxone is the other medication that might help us make sense of how we should understand Ozempic’s potential. Over the past 20 years, Suboxone’s cost — initially prohibitive to many who needed it — has decreased, and it’s gradually achieved greater acceptance in the recovery community. Regulatory barriers that prevented physicians from prescribing Suboxone have fallen, and “harm reduction,” a framework for managing addiction that tries to mitigate its worst impacts rather than require people to conform to certain behaviors, is increasingly recognized as the standard of care in addiction medicine.

And yet, Suboxone remains a heavily stigmatized, underutilized therapy largely because of its cultural associations rather than its medical risks.

The persistent dogma that people who use it aren’t really “clean” prevents people who use drugs from asking for it, and most doctors are reluctant to make it part of their practice and take on a patient population they’d rather not deal with.

Like any medication, it also comes with a host of complications: It doesn’t work for everyone, it carries a risk of side effects, it often requires a daily out-of-pocket co-pay, and people usually have to take it for the rest of their lives. It’s a very good medicine, but it doesn’t magically address all the reasons people become addicted to opioids in the first place: trauma, untreated mental-health issues, bodily pain, existential distress. It doesn’t fix a broken culture. But it does give a lot of struggling people a better chance of waking up each day to face that culture and work through everything else that ails them.
 
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WORLD WAR K aka Sensei ALMONDZ
International Member

The Moral Panic Over Ozempic Misses the Point​


The media has made the drugs about body politics and our obsession with thinness. That’s the wrong story.​

By Rachael Bedard
Illustration: Lucy Jones
d6a1c4e2bae808aec6a22a179e8835d6d8-ozempic.rhorizontal.w1100.jpg

This article was featured in One Great Story, New York’s reading recommendation newsletter. Sign up here to get it nightly.

In 2002, the FDA approved Suboxone, a new medication to treat opioid use disorder. Suboxone is a compound of two drugs that decreases one’s cravings for opioids while blocking their effects. It is safer and less cumbersome than methadone, which requires daily or weekly visits to a clinic, and more effective than any abstinence-based treatment, which requires people to withstand cravings and suppress physical discomfort. In clinical trials, Suboxone was shown to help opioid users avoid jail time and to decrease their mortality by over 50 percent. “You’d think that anything that can help save a heroin addict’s life would be seen as a good thing,” the writer and academic Michael Clune wrote in 2014, a year that marked an inflection point in an epidemic of fentanyl-related deaths. “So why, then, when I touted Suboxone at an Narcotics Anonymous meeting with a bunch of regulars did they look at me as if I’d gone insane?”
Clune has a history of heroin addiction (he wrote, to my mind, one of the great heroin-addiction memoirs) but successfully wrestled his demons into submission through a stay in rehab, diligent attendance at Narcotics Anonymous, exercise, and an enigmatic, epiphanic experience of grace. He knows how lucky he is to have overcome his addiction through struggle and also knows how rarely his strategy works for others. But when he proposed to friends in the recovery community that Suboxone is a worthy tool, they were upset; they were skeptical of a fix so expedient, so simple, so biological. “That’s like telling someone that smoking crack will get their mind off booze,” one NA longtimer argued. “Your recovery is based on a spiritual awakening,” another explained to Clune angrily. To this friend, Suboxone — a magic pill that changes the brain — would foreclose a person’s chance of personal transformation.

I thought of Clune’s essay often as I followed last year’s media coverage of Ozempic, Wegovy, Mounjaro, and other new medications that cause weight loss (from here, I’ll just use “Ozempic” as a shorthand for the whole class). Like Suboxone, Ozempic is a startlingly effective pharmacological intervention for a problem — obesity — that is common, stigmatized, complicated, and deadly. Helping people lose weight is only one of its benefits. At the homeless clinic in Brooklyn where I work as a doctor, most of the patients suffer from long-standing, intersecting chronic illnesses that doom them to trajectories of debility and decline: uncontrolled diabetes that hastens kidney disease, kidney disease that worsens high blood pressure, high blood pressure that increases the risk of heart attacks and strokes. Until recently, this was a Gordian knot that was impossible to cut with medication alone; my patients routinely take a full pharmacopeia a day and yet their conditions progress. But now, suddenly, I’m hopeful. Ozempic seems to be something of a miracle. It’s a very effective treatment for diabetes as well as high blood pressure, heart failure, and kidney disease. New evidence suggests that it improves depression and reduces suicidality, and it also seems, unexpectedly, to reduce non-food-related addictive behaviors, like gambling. Studies are underway to see if it prevents cancer and Alzheimer’s disease. There’s much more to learn, and we don’t understand how these drugs work so well. It isn’t just a matter of shedding fat and getting glucose under control; as a side effect of Ozempic’s potency, we’re gaining new insight into the relationship between mind and metabolism.
2023 was year one of the Ozempic Revolution, and the revolution has been televised, TikTok’d, Instagrammed, tweeted, and written about everywhere. Some of the coverage has been about the medications’ startling efficacy, but most of the big juicy deep dives into what the medications are, what they do, and what they mean have focused not on their astounding clinical effects but on what Ozempic reveals about our morals and values, about identity and our obsession with thinness. In magazine features, opinion pieces, and essays across prestige media, the medicines have been written about almost exclusively as a double-edged sword, a reflection of our vanities and insecurities, or an expensive, overhyped pharmaceutical ploy. The drugs have been treated as an existential threat to the still-new body-positivity movement or a shortcut primarily for the rich and already thin. Stories that have considered what the drugs could mean for the not-rich offer dour arguments that Ozempic will exacerbate health inequalities or break the health-care bank. Having emerged at the same time as AI assistants like ChatGPT, these drugs have been assessed during a broad reckoning with what it means to take the effort out of hard things. The overarching implication is that even if the medicines are as amazing as the studies claim, we can’t afford them, and even if we can afford them, we probably want them for the wrong reasons. The media class has turned Ozempic into a mirror for our cultural shortcomings, but when we stare at it primarily in search of our reflection, we miss the chance to recognize its true significance.

In October, the sociologist and writer Tressie McMillan Cottom wrote an essay for the New York Times “Opinion” section in which she says, “If GLP-1 drugs only treated diabetes and did not promote weight loss, they would still be medically groundbreaking. But Ozempic, Wegovy and Mounjaro probably would not have social media hashtags. These drugs are blockbusters because they promise to solve a medical problem that is also a cultural problem — how to cure the moral crisis of fat bodies that refuse to get and stay thin.” In her piece, McMillan Cottom makes mention of diabetes and the murky category of prediabetes, but her discussion dwells primarily on what she sees as the drugs’ cultural implications: the way they function as “a shorthand for our coded language of shame, stigma, status and bias around fatness.” McMillan Cottom’s distinction between the “medical problem” and “cultural problem” of obesity is a common theme of the Ozempic coverage; most pieces offer an obligatory nod toward the drug’s therapeutic effects but then are most eager to discuss its implications for body politics.
The first wave of Ozempic coverage was largely about celebrities — were Julia Fox and Kim Kardashian taking it? — which set the themes that would define the Ozempic discourse that followed: vanity, beauty standards, and class. In February 2023, in this magazine, Matthew Schneier wrote a cover story in which he profiled actresses, artists, and fashion employees who were taking the medication to shed ten pounds. “Weren’t we supposed to have moved on from this?” Schneier wondered — “this” referring to the tale as old as time of women chasing trends to look more svelte. In March, The New Yorker writer Jia Tolentino ordered bootleg Ozempic through a pill-mill-type service to prove its ready availability to anyone with a credit card.
Once the drug seemed to be everywhere, some writers struggled with whether taking it might mean abandoning their commitment to body positivity. In the Cut, Samhita Mukhopadhyay wrote a vulnerable essay about her reluctance to take Mounjaro. “I was too ashamed to say it out loud,” she wrote, “but the drug was working, and I wasn’t sure how I felt about it.” In August, Emma Specter wrote in Vogue about how she would have wanted the drug five years ago but was now at a more radical place of self-acceptance. “What would we do — who would we be — if we let our bodies and lives exist more or less as they are, without looking to drugs like Ozempic to free us from the eternal trap of bodily perfection?” Specter asked.
The cultural and emotional implications of the drug’s weight-loss effects, especially shame, became a recurrent theme. In the New York Times, Aaron Carroll, a physician, wrote about overcoming his own resistance to trying the medicine for weight loss, and in the Washington Post, Ruth Marcus published a long reported essay about her initially ambivalent experience taking Ozempic in which she confessed, “As my weight loss began to show … I realized that I had internalized the sense that being heavy was a failing for which I was personally responsible.” In early summer, the New York Times published a story with the headline “New Obesity Drugs Come With a Side Effect of Shaming” and then reprised the topic during the holidays: “Plates are full. Families may be quick to judge. What happens when weight-loss drugs collide with Thanksgiving?” As the year drew to a close, Ozempic’s implications for “the eternal trap of bodily perfection” remained a focus: In late December, Jennifer Weiner wrote in the New York Times about Oprah Winfrey’s choice to take one of these medications, claiming that Winfrey’s public weight struggles had reinforced the idea that “every woman’s body is a battleground … and that thinness is a woman’s true life’s work.”
Meanwhile, new information about Ozempic was emerging in the medical literature. By December, the results of the SELECT trial had been announced: It turns out that Ozempic reduces heart attacks, strokes, and cardiovascular mortality for people who are overweight, even if they don’t have diabetes. We also had initial results from the FLOW trial, suggesting that Ozempic prevents diabetics with kidney disease from needing dialysis. Forty percent of Americans are obese, and 12 percent have diabetes. These results suggest that Ozempic might change the shape and length of their lives more than anything we’ve previously had to offer.
In my job, I regularly encounter the type of story that I wish we were telling about Ozempic. Recently, I met a woman I’ll call Arlene. Arlene has bad diabetes and is about 80 pounds overweight. Diabetes is a hard condition to manage; injecting insulin causes weight gain, so treating it often causes a person’s obesity to worsen. Arlene lives in a shelter where she eats what the shelter serves her, which is basically shit, and she’s in a wheelchair, which prevents her from exercising. We had a hard, tearful visit because a lot is going wrong in her life and she’s under significant stress. But one thing was going well. A few weeks before I met her, a specialist had started Arlene on Ozempic. In four weeks, Arlene had lost almost ten pounds. Her blood sugar was already in much better control, and she thought her back pain had improved. Arlene used the word “miracle” to describe the effects; the medication was the first thing in a long time to make her feel hopeful.
People like Arlene remain curiously absent from the Ozempic discourse, and they don’t seem to be anyone’s imagined reader, either. Not one of the first-person essays and opinion pieces that I read last year was written by a person with serious chronic illness. Never hearing this perspective means we don’t actually understand the experiences of the people who most stand to gain from Ozempic’s arrival. All medical problems are cultural problems — all illnesses exacerbate structural inequalities and provoke identity questions and elicit stigma — but by now, the cultural implications of struggling with one’s weight are so well covered that they have spawned a kind of genre writing. In all of the stories I’ve mentioned — and in similar coverage in The Atlantic, Slate, and elsewhere — “Ozempic” plays the same role that “Weight Watchers” or “diet culture” or “plastic surgery” have played in stories written over the past 30 years. Despite everything we now know about Ozempic’s radical therapeutic potential, we’re still calling it a “weight-loss drug,” which allows us to keep it in a zone of moral ambivalence and interpret it using familiar conventions.
Conversely, we don’t have popular, well-developed narratives about the chronic diseases that result from glucose derangement and excess fat tissue, which disproportionately debilitate people who are poor and racialized. We have the cultural elite’s obsession with Susan Sontag’s Illness As Metaphor, we have cancer memoirs, and we have an emerging post-pandemic literature about the vagaries and difficulties of living with long COVID. We have no canon of great writing about struggling with cirrhosis or the decision to get a diabetic amputation. “There aren’t breathless profiles of a pharmaceutical drug because it will help a diabetic manage her blood glucose level,” McMillan Cottom observed in her essay. She’s right. America’s silent majority of chronic-disease sufferers — dying prematurely, disabled, or on dialysis — desperately need this drug. For them, taking this medication and losing weight isn’t a question of succumbing to vanity or vanquishing one’s inner critic.

Elite media discourse around Ozempic can meaningfully influence public opinion and health-care policy. Right now, the most urgent concern about Ozempic is the fact that everyone who needs and wants it cannot get it. Recently, the state of North Carolina had to rescind its policy of paying for the drugs for people who do not have diabetes — in other words, people prescribed the medications primarily for weight loss — because it could no longer afford the ballooning costs. The drugs can cost up to $16,000 a year (depending on the one prescribed), an out-of-pocket cost few people can bear.
So far, the public discussion of Ozempic’s daunting economics have been consistently fatalistic. At the end of the summer, the columnist Megan McArdle and the physician Leana Wen wrote op-eds in the Washington Post within two months of each other saying the cost benefit for the drugs may not pencil out. Nearly every story I’ve read has used the current access challenges as reason to doubt the drug’s miracle status: If it’s only going to be available to the luckiest few, what makes it any better than Botox? Jia Tolentino, in The New Yorker, wrote, “It is possible to imagine a different universe in which the discovery of semaglutide was an unalloyed good … In the actual universe that we inhabit, the people who most need semaglutide often struggle to get it, and its arrival seems to have prompted less a public consideration of what it means to be fat than a renewed fixation on being thin.”
As long as we talk about these medications primarily as “weight-loss drugs” — as medications that have prompted “a renewed fixation on being thin” — insurance companies and policymakers will remain incentivized to treat them as a luxury good. We’ll never ask the questions that need to be asked: If such a large percentage of the country wants Ozempic, and if we now have good-quality evidence that it helps with a variety of serious conditions beyond diabetes, what is our cutoff for determining who truly needs it? And how do we make it available to them? Price is not an inherent feature of most pharmaceuticals. Ozempic already costs less in other countries, and in the U.S., the president recently took the extraordinary step of lowering drug costs for some of the most commonly prescribed medications by using his executive authority. Ozempic presents a radical opportunity to change the chronic-disease landscape in this country. It may require radical policy to make it accessible, and what that policy looks like is the conversation I want to have.
In a culture where we so powerfully associate wealth, beauty, and thinness, I wonder if we simply can’t envision recategorizing a medicine like Ozempic, something rich people want, as an intervention for the non-rich. We are comparing Ozempic to the wrong precedents — fen-phen in the 1990s gets mentioned a lot; McMillan Cottom compares the hype it’s received to Botox and Viagra — and missing the analogies that would be most helpful. In a hopeful end-of-year story in The New Yorker, Dhruv Khullar compares Ozempic to COVID therapies and the COVID vaccine: interventions that made an overwhelming, seemingly intractable public-health crisis suddenly much less so. The comparison is a useful one, because it also points toward how Ozempic’s initial access issues do not mean that it cannot, ultimately, play a powerful role in reducing health disparities. Initial coverage of the COVID vaccine focused a lot on the equity concerns surrounding who would get it first. And yet, because the vaccine was disproportionately beneficial to the populations most vulnerable to serious COVID outcomes, the poor, sick, and elderly were ultimately most helped by it, even if they got it two months later than they should have.
Suboxone is the other medication that might help us make sense of how we should understand Ozempic’s potential. Over the past 20 years, Suboxone’s cost — initially prohibitive to many who needed it — has decreased, and it’s gradually achieved greater acceptance in the recovery community. Regulatory barriers that prevented physicians from prescribing Suboxone have fallen, and “harm reduction,” a framework for managing addiction that tries to mitigate its worst impacts rather than require people to conform to certain behaviors, is increasingly recognized as the standard of care in addiction medicine.
And yet, Suboxone remains a heavily stigmatized, underutilized therapy largely because of its cultural associations rather than its medical risks. The persistent dogma that people who use it aren’t really “clean” prevents people who use drugs from asking for it, and most doctors are reluctant to make it part of their practice and take on a patient population they’d rather not deal with. Like any medication, it also comes with a host of complications: It doesn’t work for everyone, it carries a risk of side effects, it often requires a daily out-of-pocket co-pay, and people usually have to take it for the rest of their lives. It’s a very good medicine, but it doesn’t magically address all the reasons people become addicted to opioids in the first place: trauma, untreated mental-health issues, bodily pain, existential distress. It doesn’t fix a broken culture. But it does give a lot of struggling people a better chance of waking up each day to face that culture and work through everything else that ails them.
Negro did u just post 50 years of research lol
 

Pworld297

Rising Star
BGOL Investor
I just got one last week, only cost me $12 with my insurance. I asked my doctor about it and she prescribed it for me. My main concern is my AC1 number which has went up because I've gained weight this past year. If it helps me lose weight ok but I'm still cleaning my diet up and going to exercise more. I don't smoke and I rarely drink alcohol. I will let y'all know how it goes the next few months.
 

Famous1

Rising Star
Platinum Member
goddamn condense that shit or give us the cliff notes version
Basically... Ozempic is fucking with the church's money. Semaglutide( Ozympic ) is a peptide that controls your blood sugar and helps you to lose weight... The weight loss industry is huge..extra weight leads to other health problems which leads to $$$$ for big Pharma. You can get Semaglitude without a script...
 

trstar

Rising Star
BGOL Investor
I just got one last week, only cost me $12 with my insurance. I asked my doctor about it and she prescribed it for me. My main concern is my AC1 number which has went up because I've gained weight this past year. If it helps me lose weight ok but I'm still cleaning my diet up and going to exercise more. I don't smoke and I rarely drink alcohol. I will let y'all know how it goes the next few months.
$12! What’s the dosage ?
 

therealjondoe

Rising Star
BGOL Investor
I just got one last week, only cost me $12 with my insurance. I asked my doctor about it and she prescribed it for me. My main concern is my AC1 number which has went up because I've gained weight this past year. If it helps me lose weight ok but I'm still cleaning my diet up and going to exercise more. I don't smoke and I rarely drink alcohol. I will let y'all know how it goes the next few months.
You have to take it for the rest of your life or you will gain the weight back
 

THREAD_CRITIC

Rising Star
BGOL Investor
You have to take it for the rest of your life or you will gain the weight back

nah may coworker took it for a year lost mad weight got his A1C to normal levels cancelled his insurance by mistake so the cost went from $28 a pen to $1000 without insurance he stopped taking it but maintains a healthy lifestyle works out dude looks amazing.
 
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keone

WORLD WAR K aka Sensei ALMONDZ
International Member
I just got one last week, only cost me $12 with my insurance. I asked my doctor about it and she prescribed it for me. My main concern is my AC1 number which has went up because I've gained weight this past year. If it helps me lose weight ok but I'm still cleaning my diet up and going to exercise more. I don't smoke and I rarely drink alcohol. I will let y'all know how it goes the next few months.
Sugar just as deadly
I would say even more
 

LordSinister

One Punch Mayne
Super Moderator
I couldn't take it. I was/am rehabbing and found myself grabbing handfuls of Jolly Ranchers at the physical therapist. I switched to Manjaro and I'm happy to say my A1C is back to normal. Once I can get back to strength training, I won't need it anymore.
 

Famous1

Rising Star
Platinum Member
I couldn't take it. I was/am rehabbing and found myself grabbing handfuls of Jolly Ranchers at the physical therapist. I switched to Manjaro and I'm happy to say my A1C is back to normal. Once I can get back to strength training, I won't need it anymore.
Manjaro (Tirzapeptide)....has the extra benefit of making you feel full so you won't even want those jolly ranchers. Get you some BPC-157 to help with your rehab....recover like Wolverine....
I fucks with my peptides...

share images
 

Famous1

Rising Star
Platinum Member
You have to take it for the rest of your life or you will gain the weight back
if you don't put them got damn twinkies and oreo's down....yep, the weight will come back. With any method of weight loss, If you continue to do the same things you did before you lost the weight, it's coming back. Even surgery. (basically what bbuzzard said above)
 

34real

Rising Star
Registered
...Just like having surgery to lose weight,it can work but what are you going to do after you heal and you get back to regular life?I know of 3 broads who had the Dr.Now surgery,lost lots of weight,looked good and a year after gained it back and one of the ladies gained more she's like 500+ pounds now.

It's more mental than anything else....
 

playahaitian

Rising Star
Certified Pussy Poster

I Definitely Would Have Taken Ozempic to Lose Weight Five Years Ago—But What Else Would I Have Lost?​

BY EMMA SPECTER
August 8, 2023
Ozempic  injecting pen against pinkish background

Photo: Getty Images

I am so, so sick of Ozempic. Not necessarily the drug itself—which is one of a family of brand-name versions of the antidiabetic medication semaglutide and was approved by the FDA in 2021, under the brand name Wegovy, for the purpose of weight management in adults with obesity who had at least one comorbidity. What I’m really sick of is the discourse around Ozempic, Wegovy, Mounjaro, and other weight-loss injectables, which have taken Hollywood by storm and found new life on TikTok (where, depressingly enough, the #Ozempic hashtag has more than a billion posts associated with it).
I don’t know exactly why the Ozempic discourse drives me so crazy. I’ve spent years coming to terms with my own identity as a fat person and trying to internalize the idea that nobody gets to have an opinion on my body—nor should I have an opinion on anyone else’s. Still, when I see celebrities like Amy Schumer—whose weight has been as obsessively discussed as anything else in her life or career, whether she liked it or not—speak openly about using Ozempic, the fatphobic part of my brain I thought I’d excised long ago panics and whispers: Should I be doing it too?




Realistically, joining the Ozempic craze would hardly be so simple. First of all, the drug tends to run at about $900 for a monthly supply (which, together with my rent, would definitely help me lose weight, as I’d no longer be able to afford food); then there’s the fact that the last time I saw my doctor, she specifically told me that weight-loss injectables aren’t an ideal fit for someone with my history of disordered eating and weight fluctuation. I’ve also spent a long time reading the work of writers like Virgie Tovar, Virginia Sole-Smith, and Sabrina Strings, all of whom take care to place our society’s obsession with thinness in its appropriate cultural context and remind their readers that there is no inherent value in working overtime to make your body look a certain way.

Some days it feels like I’m wrestling with bodily anxiety as much as I ever did—but I know that’s not truly the case, largely thanks to all the reading I’ve done since 2019, when I first began to gain a significant amount of weight. Five or six years ago, though—when I was in my early 20s and still thin, not yet out as queer, and struggling to make my life take any sort of shape beyond the confines of my then all-consuming binge-eating disorder and depression—I know with a sad kind of certainty that I would have done almost anything to get my hands on Ozempic, or any other drug that promised to make me disappear, no matter how expensive it was or what my doctor said to try to dissuade me.


One of the most perplexing things about the eating-disorder mindset is how dramatically it can shrink your world, hiding from view all the things you know should matter to you (relationships with friends and family, dating, work, etc.) as you focus more and more narrowly on the shimmering mirage of thinness. I was taken in by that mirage day in and day out when I was 23 or 24, sure that if I could just limit my binges and replace them with periods of (let’s call it what it is) starvation, I’d have all the love and luck and professional and personal success I could dream of. I was afraid of taking real risks in my life, so I took them with my food, alternately stuffing myself to the point of nausea and trying to make it through a punishing bike ride through LA on zero calories. I’ve finally come into some measure of compassion for that former version of myself, but I worry that if she’d had access to Ozempic, she would have narrowly avoided the five years that followed—years of going to regular therapy, reading Roxane Gay and Lindy West, finding an ED-trained nutritionist, and finally, maybe inevitably, gaining the weight she’d long feared but learning to mostly be okay with it—and lost something crucial in the process.
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I don’t want to imply that my path toward tenuous body peace is the only acceptable one, and I really don’t want to judge anyone who’s using Ozempic or its sister drugs to lose weight. No, the drug may not be right for me, but I can’t dictate what works for other people, and all the nasty gossip swirling about who’s on Ozempic just feels like yet another way of telling people (and women, in particular) that any way we live in our bodies is fundamentally wrong. I do have high hopes for the 23-year-olds of today, though, especially the ones who—like me at their age—are still buying into the societally endorsed fallacy that thinness is a shortcut toward happiness. I want better for them. I don’t want them to feel obligated to spend their precious time, money, and energy chasing weight loss. What would we do—who would we be—if we let our bodies and lives exist more or less as they are, without looking to drugs like Ozempic to free us from the eternal trap of bodily perfection? What could an extra $900 a month and a haltingly declared freedom from the tyranny of diet culture buy us, if we were brave enough (and, more to the point, societally supported enough) to find out?
 

playahaitian

Rising Star
Certified Pussy Poster

Mounjaro and Me​


Body positivity was my salvation from an anti-fat world. Then I was prescribed an injectable weight-loss drug that upended everything.​

Portrait of Samhita Mukhopadhyay
By Samhita Mukhopadhyay, a Cut contributor since 2021

Photo: Jasmin Merdan/Getty Images

Two months ago, I was at a party when I overheard two friends talking about “Ozempic face.” I only caught the tail end of the conversation, but it was enough to pick up on the tone of judgment in their voices and looks of horror at the idea of women taking these new “diet drugs.”

My hair stood up on the back of my neck, and I felt a lump in my throat — I tried to say that the drug doesn’t really age your face, it’s just the changes that happen when you lose weight, but I trailed off. I’m usually immune to well-meaning, offhanded comments about weight and wellness: from diet trends to new exercise regimens, and from talk about how fat people should be more health-conscious to the idea that fatness itself is an epidemic.

But this time was different. What my friends didn’t know is that I was already on one of those drugs. I was too ashamed to say it out loud, but the drug was working, and I wasn’t sure how I felt about it.

I want to say it all started six months ago, but that’s not really true.

I’ve lived most of my life as a “curvy” girl — the “you have such a pretty face” girl — but otherwise fit into standard sizes until the last few years. As my size changed, so did the way the world treated me — the eye rolls when I found my seat on the plane, the invisibility when out with thinner friends, the mean comments from nosy family members, the suspicion that I’d been overlooked for promotions.
I could write books, run a newsroom, provide for my family, be a good friend, and be on time for anything, but I couldn’t be thin or get thin — and, somehow, that felt like it negated everything else. What was the point of all this success if I’m still fat?

We live in an anti-fat culture where weight gain is, on its own, seen as a personal failure. (Weight loss, on the other hand, is viewed as a sign of sacrifice and commitment — you have to earn it to be worthy of it, as writer Helen Rosner points out). Fat people like me have a harder time getting appropriate medical care; we face discrimination in finding work and housing; we are humiliated when flying; we are disbelieved when raped. We are ridiculed and shamed, whether when teased as children or heckled in public as adults.

In the last few years, I found respite in the body-positivity movement, which posits that none of us deserve to be humiliated or discriminated against because of our sizes. And I’ve worked hard to love myself at my size: I refuse to try a fad diet, refuse to follow extreme exercise regimens, refuse to do anything that I perceive as giving in to the pressure to constantly obsess about my weight and hate my body.

Around the same time that I slid across the curvy divide and into fat-landia, my father, who had struggled with obesity-related diabetes and heart disease for most of his adult life, died of complications from his diabetes and the resulting dialysis. It was not an easy death — and it was made worse by my own recognition that, on some level, I had believed he could’ve stayed with us had he taken better care of his body in exactly the ways I lately wasn’t taking care of my own.

Eight months ago I found myself tired all the time, tossing and turning at night, overheating. I’d lose my breath exerting myself. I was eating compulsively and struggling to take care of myself. When you are fat, though, it’s hard to know what you actually need and harder to know how to get it.

The thought of going to a health-care provider who might be rude or shame me about my weight — let alone put me through a cycle of self-punishment that would add to my mental health woes — had made me avoid the reality of my health for two years. Finally, one day I woke up so exhausted that I couldn’t focus, and I knew I had to take action. I needed to do something about my health without going back to hating my body.

Six months ago, after some research, I found a doctor, a woman of color who had investigated generational health issues in her own family, who appeared to have a holistic approach to weight and health, and finally booked an appointment. My bloodwork showed that I wasn’t diabetic, but I was as close as you can get; my cholesterol was elevated, but not to the point that I needed to be on medication. I was at the stage at which patients are usually encouraged to try keeping a food diary, drinking more water, getting more exercise, and cutting calories, all in a mild lead-up to some sort of herculean weight-loss effort we all know won’t really work forever anyway. I explained that I knew short-term dieting didn’t and wouldn’t work for me, but I was struggling to make any meaningful long-term lifestyle changes.

My doctor suggested I try weight-loss medication.

In particular, she suggested that we try a newer class of these drugs — either semaglutides or tirzepatides — that were developed to treat diabetes but have also shown great success in helping patients lose weight. Some, like Ozempic and Mounjaro, are currently only approved for people with diabetes, those who have a high risk of developing diabetes, or those who are prediabetic with high A1C (a number that tells you how much sugar is in your blood and if you are nearing diabetes), while others, like Wegovy, are approved for weight loss in overweight and obese people. All are injectables that mimic your own hormones (what doctors call GLP-1 or GIP) that are supposed to control our feelings of hunger and make us feel full sooner when eating. (They are also really expensive for people without insurance, which doesn’t always even cover them, and their recent off-label overuse has resulted in these drugs becoming less available to patients with diabetes. )

She said taking one — she recommended Mounjaro — would help suppress my appetite and bring down my blood sugar while I slowly make some gradual-but-permanent lifestyle changes like moving a little each day and eating higher-quality foods.

I walked out of the doctor’s office white hot with shame about my health, despite my doctor’s optimism. How could I let it get this bad? Was I now my father? And, beyond that, the thought of taking a “weight loss” drug felt both like giving up on and a betrayal of the body positivity I’d struggled so hard to achieve.

I did what I always do when faced with a major life decision: I started talking to people — other doctors (“This drug is revolutionary”); friends who have faced similar questions (“Would you judge someone that needs an inhaler for their asthma?”); and, worst of all, I talked to straight-size people. “Do you really need this medication yet?” one friend asked me. “Have you really tried everything else?”
I realized something awful in this process: Not only do I struggle with the belief that the size of my body is my fault and a result of my neglectful actions, some other people feel that way, too.

But after many appointments and many questions, I decided to go on the drug. I knew I needed some kind of intervention to help stabilize my body and my health while I figured out why I was eating my feelings, why I was struggling to even go for a walk, and why I thought good health and self-care were only about sacrifice. I had to interrogate why I believed I deserved to be sick because I couldn’t “control” myself, but I couldn’t allow myself to keep getting sicker while I did so.

So now I’ve been on Mounjaro for several months, and each time I want to refill my prescription, I have to go to visit the doctor to talk through how I’m feeling, how the side effects — constipation, nausea, some insomnia — are going and how my relationship to food and my body are changing. (Because my doctor is a holistic practitioner, and because I made it very clear I don’t want to be on this for longer than I need to be, this is slightly above and beyond as I understand it.) It’s been an adjustment. Behavior change is not impossible; it’s just really, really hard, and a drug like this is meant to be one tool of many, which for me includes therapy, movement, and mindfulness.

And I have lost some weight, though not the enormous amounts you read about in some breathless reporting. It’s given me some space to breathe between meals — and it’s even helped me crave healthier foods. (It apparently makes it harder to digest greasy, fried, and sugary foods). My A1C has dropped 0.5 points, a strong indicator that my genetics don’t mean I have to develop diabetes, which has given me a tremendous sense of relief. That’s what I’m staying focused on — my actual health and the indicators that determine it, even if everything and everyone wants me to just focus on losing weight.

But, perhaps most profoundly, having a medication that can regulate my hormones is teaching me that when I eat compulsively, it is not just about internal willpower or self-control. And that when such behavior began threatening my health, it was okay to get help. Getting treatment was not a personal failure; it was good medical care for me.

Undoubtedly, anything touted as a “weight-loss miracle” is troubling because, as writer Aubrey Gordon said on Slate’s The Waves podcast recently, “when we get this spun up about a weight-loss drug this early, it’s usually a bad sign because it means that people will get more attached to the fantasy of weight loss.” (Also, it’s worth noting, the long-term effects of these drugs are still being studied.)

What these drugs can’t fix is what underlies the “obesity epidemic” — a culture that continues to hate fat people, a health-care system that incentivizes our weight loss over our actual well-being, and a food system that denies us access to whole, healthy foods.

But my body alone can’t remedy all that. Perhaps it was my commitment to body positivity’s insights into the diet industry that made me hesitant to consider a drug that would result in weight loss. Until I realized that body positivity is also about doing what is right for you and your body as you see it. Allowing myself to step away from the externally imposed shame and the sense of impossibility that has come with living in this body and really trying to figure out what is best for myself ended up being the key to truly accepting myself.
 

0utsyder

Rising Star
BGOL Investor
You have to take it for the rest of your life or you will gain the weight back
I mean you have to workout and eat healthy for the rest of your life. I don't want to give people an excuse for a drug that is supposed to help with diabetes, but you get to a certain weight and stop exercising you gain weight and lose strength.
 

Akata King

D3port Th3m @ll!!
BGOL Investor

They Thought Ozempic Would Help Them Lose Weight. It Didn’t Work.​

There is a wide range in how much weight people lose on GLP-1 medications​


April 1, 2024 5:30 am ET


Behind the blockbuster success of drugs like Ozempic and Wegovy is a less-noticed phenomenon: Some people don’t lose much weight on them.

There is wide variation in weight loss on these types of drugs, called GLP-1s. Doctors say roughly 10% to 15% of people who try them are “non-responders,” typically defined as those who lose less than 5% of their body weight. These patients, doctors say, don’t experience enough appetite reduction to result in significant weight loss.

Researchers are studying why some people drop a lot of weight on them while others lose little. The answers might yield broader clues about weight loss and provide more insight into these medications, which have transformed the way Americans lose weight.

Doctors believe some people might be resistant to the drugs as a result of genetic differences. Other possible reasons could include certain medical conditions and medications, how much weight a person lost before taking the drugs, and differences in how people metabolize them.

Wide range of weight loss​

In a trial for the drug semaglutide—marketed as Wegovy and Ozempic—about 14% of patients lost less than 5% of their body weight. About a third lost less than 10%. In a trial for tirzepatide, sold as Mounjaro and Zepbound, 9% of people lost less than 5% of their body weight and 16% lost less than 10%.

Even among those who lost weight, amounts ranged from around 5% to upward of 20%.

“There’s going to be extreme variability in how people respond,” says Dr. Eduardo Grunvald, an obesity-medicine physician at UC San Diego Health.

Anthony Esposito, a 68-year-old in Austin, Texas, whose body-mass index puts him in the overweight category, wanted to take a GLP-1 drug to lose about 10 pounds. He stopped Wegovy after a month because it made him feel sick, and then tried Ozempic for about six weeks. Esposito says that he didn’t lose a pound and that his appetite remained the same.

“It did not budge the needle,” he says.

For other people, initial success fizzles. Melissa Traeger, a 40-year-old in Nashville, Tenn., started off at nearly 300 pounds and lost about 10 in the first six weeks. Then the weight loss stalled. She shed another few pounds in the next couple of months, leveling off at 285.

“There was appetite suppression the first one-and-half months but it’s kind of just fallen off after that,” she says. Traeger plans on switching to another GLP-1 medication.

Novo Nordisk, which makes Ozempic for Type 2 diabetes and Wegovy for obesity, says that not all patients will respond to all therapies, and notes that the overwhelming majority of patients treated with Wegovy lost some weight in the semaglutide trial.

Eli Lilly, which markets Mounjaro for diabetes and Zepbound for obesity, says that obesity is a heterogeneous disease and that most people in its clinical studies achieved at least a 20% weight loss at the highest dose.

Why results vary​

Obesity in some people might be driven by something besides the hormones that weight-loss drugs mimic to suppress appetite, says Grunvald. In those cases, the drugs probably won’t make much of a difference.

People who have had obesity their whole lives might have genetic mutations preventing them from responding strongly to the drugs, says Dr. Steven Heymsfield, a professor who studies obesity at Louisiana State University’s Pennington Biomedical Research Center. And people who metabolize the drugs quickly might not experience as much of an effect, he says.

Other medical issues could dampen the effect of weight-loss drugs. People with Type 2 diabetes typically lose less than those without the condition, Grunvald says.

Diet and exercise habits before starting the drugs can influence how much weight one loses. People who have already shed a lot of weight through lifestyle changes might not drop much more on the drugs, Grunvald says.

Other medications can play a role, too. Many drugs—such as certain types of antidepressants and antipsychotics—have weight gain as a side effect.

You could have some other drug interactions that prevent the effect of the GLP-1 drugs from working,” says Heymsfield.

If the drugs don’t work​

When people don’t respond to a GLP-1, Grunvald says he looks to see if there is room for improvement in diet and exercise. Then he will suggest trying a different drug in the same class, or adding other medications, such as an older weight-loss drug. Physicians will also discuss bariatric surgery with patients who meet the criteria.

Doctors typically have patients try the new drugs for three to six months and increase the dose each month to see if patients respond.

Dr. Gitanjali Srivastava, an associate professor and co-director at the Vanderbilt Weight Loss Center, says she had a patient who tried multiple GLP-1 medications and none worked. The patient did respond to one of the older weight-loss medications that typically don’t result in as much weight loss.

Genetic testing can yield clues for patients who have had obesity since childhood and are entirely resistant to even the highest doses of Mounjaro, says Dr. Myra Ahmad, chief executive of Mochi, a telehealth obesity clinic. If they test positive for certain genes, they can try a medication for genetically linked obesity, she says.

Battling frustration​

Even when people don’t lose weight on the GLP-1 drugs, they might be improving health in other ways, such as lowering blood-sugar levels and helping to manage diabetes.

“Considering ‘response’ solely in terms of weight loss, and not broader outcomes for health and quality of life, overlooks many of the benefits seen with treating obesity beyond weight loss,” says Dr. Jaime Almandoz, medical director of the Weight Wellness Program and associate professor of internal medicine at UT Southwestern in Dallas.

Still, for people who have been hoping the new drugs will be a panacea, not losing weight on them can be frustrating.

Some have been struggling with weight for years, and might have already tried bariatric surgery or older medications. “Yet another option not working can feel very demoralizing,” says Ahmad.

 

Famous1

Rising Star
Platinum Member

Mounjaro and Me​


Body positivity was my salvation from an anti-fat world. Then I was prescribed an injectable weight-loss drug that upended everything.​

Portrait of Samhita Mukhopadhyay
By Samhita Mukhopadhyay, a Cut contributor since 2021

Photo: Jasmin Merdan/Getty Images

Two months ago, I was at a party when I overheard two friends talking about “Ozempic face.” I only caught the tail end of the conversation, but it was enough to pick up on the tone of judgment in their voices and looks of horror at the idea of women taking these new “diet drugs.”

My hair stood up on the back of my neck, and I felt a lump in my throat — I tried to say that the drug doesn’t really age your face, it’s just the changes that happen when you lose weight, but I trailed off. I’m usually immune to well-meaning, offhanded comments about weight and wellness: from diet trends to new exercise regimens, and from talk about how fat people should be more health-conscious to the idea that fatness itself is an epidemic.

But this time was different. What my friends didn’t know is that I was already on one of those drugs. I was too ashamed to say it out loud, but the drug was working, and I wasn’t sure how I felt about it.

I want to say it all started six months ago, but that’s not really true.

I’ve lived most of my life as a “curvy” girl — the “you have such a pretty face” girl — but otherwise fit into standard sizes until the last few years. As my size changed, so did the way the world treated me — the eye rolls when I found my seat on the plane, the invisibility when out with thinner friends, the mean comments from nosy family members, the suspicion that I’d been overlooked for promotions.
I could write books, run a newsroom, provide for my family, be a good friend, and be on time for anything, but I couldn’t be thin or get thin — and, somehow, that felt like it negated everything else. What was the point of all this success if I’m still fat?

We live in an anti-fat culture where weight gain is, on its own, seen as a personal failure. (Weight loss, on the other hand, is viewed as a sign of sacrifice and commitment — you have to earn it to be worthy of it, as writer Helen Rosner points out). Fat people like me have a harder time getting appropriate medical care; we face discrimination in finding work and housing; we are humiliated when flying; we are disbelieved when raped. We are ridiculed and shamed, whether when teased as children or heckled in public as adults.

In the last few years, I found respite in the body-positivity movement, which posits that none of us deserve to be humiliated or discriminated against because of our sizes. And I’ve worked hard to love myself at my size: I refuse to try a fad diet, refuse to follow extreme exercise regimens, refuse to do anything that I perceive as giving in to the pressure to constantly obsess about my weight and hate my body.

Around the same time that I slid across the curvy divide and into fat-landia, my father, who had struggled with obesity-related diabetes and heart disease for most of his adult life, died of complications from his diabetes and the resulting dialysis. It was not an easy death — and it was made worse by my own recognition that, on some level, I had believed he could’ve stayed with us had he taken better care of his body in exactly the ways I lately wasn’t taking care of my own.

Eight months ago I found myself tired all the time, tossing and turning at night, overheating. I’d lose my breath exerting myself. I was eating compulsively and struggling to take care of myself. When you are fat, though, it’s hard to know what you actually need and harder to know how to get it.

The thought of going to a health-care provider who might be rude or shame me about my weight — let alone put me through a cycle of self-punishment that would add to my mental health woes — had made me avoid the reality of my health for two years. Finally, one day I woke up so exhausted that I couldn’t focus, and I knew I had to take action. I needed to do something about my health without going back to hating my body.

Six months ago, after some research, I found a doctor, a woman of color who had investigated generational health issues in her own family, who appeared to have a holistic approach to weight and health, and finally booked an appointment. My bloodwork showed that I wasn’t diabetic, but I was as close as you can get; my cholesterol was elevated, but not to the point that I needed to be on medication. I was at the stage at which patients are usually encouraged to try keeping a food diary, drinking more water, getting more exercise, and cutting calories, all in a mild lead-up to some sort of herculean weight-loss effort we all know won’t really work forever anyway. I explained that I knew short-term dieting didn’t and wouldn’t work for me, but I was struggling to make any meaningful long-term lifestyle changes.

My doctor suggested I try weight-loss medication.

In particular, she suggested that we try a newer class of these drugs — either semaglutides or tirzepatides — that were developed to treat diabetes but have also shown great success in helping patients lose weight. Some, like Ozempic and Mounjaro, are currently only approved for people with diabetes, those who have a high risk of developing diabetes, or those who are prediabetic with high A1C (a number that tells you how much sugar is in your blood and if you are nearing diabetes), while others, like Wegovy, are approved for weight loss in overweight and obese people. All are injectables that mimic your own hormones (what doctors call GLP-1 or GIP) that are supposed to control our feelings of hunger and make us feel full sooner when eating. (They are also really expensive for people without insurance, which doesn’t always even cover them, and their recent off-label overuse has resulted in these drugs becoming less available to patients with diabetes. )

She said taking one — she recommended Mounjaro — would help suppress my appetite and bring down my blood sugar while I slowly make some gradual-but-permanent lifestyle changes like moving a little each day and eating higher-quality foods.

I walked out of the doctor’s office white hot with shame about my health, despite my doctor’s optimism. How could I let it get this bad? Was I now my father? And, beyond that, the thought of taking a “weight loss” drug felt both like giving up on and a betrayal of the body positivity I’d struggled so hard to achieve.

I did what I always do when faced with a major life decision: I started talking to people — other doctors (“This drug is revolutionary”); friends who have faced similar questions (“Would you judge someone that needs an inhaler for their asthma?”); and, worst of all, I talked to straight-size people. “Do you really need this medication yet?” one friend asked me. “Have you really tried everything else?”
I realized something awful in this process: Not only do I struggle with the belief that the size of my body is my fault and a result of my neglectful actions, some other people feel that way, too.

But after many appointments and many questions, I decided to go on the drug. I knew I needed some kind of intervention to help stabilize my body and my health while I figured out why I was eating my feelings, why I was struggling to even go for a walk, and why I thought good health and self-care were only about sacrifice. I had to interrogate why I believed I deserved to be sick because I couldn’t “control” myself, but I couldn’t allow myself to keep getting sicker while I did so.

So now I’ve been on Mounjaro for several months, and each time I want to refill my prescription, I have to go to visit the doctor to talk through how I’m feeling, how the side effects — constipation, nausea, some insomnia — are going and how my relationship to food and my body are changing. (Because my doctor is a holistic practitioner, and because I made it very clear I don’t want to be on this for longer than I need to be, this is slightly above and beyond as I understand it.) It’s been an adjustment. Behavior change is not impossible; it’s just really, really hard, and a drug like this is meant to be one tool of many, which for me includes therapy, movement, and mindfulness.

And I have lost some weight, though not the enormous amounts you read about in some breathless reporting. It’s given me some space to breathe between meals — and it’s even helped me crave healthier foods. (It apparently makes it harder to digest greasy, fried, and sugary foods). My A1C has dropped 0.5 points, a strong indicator that my genetics don’t mean I have to develop diabetes, which has given me a tremendous sense of relief. That’s what I’m staying focused on — my actual health and the indicators that determine it, even if everything and everyone wants me to just focus on losing weight.

But, perhaps most profoundly, having a medication that can regulate my hormones is teaching me that when I eat compulsively, it is not just about internal willpower or self-control. And that when such behavior began threatening my health, it was okay to get help. Getting treatment was not a personal failure; it was good medical care for me.

Undoubtedly, anything touted as a “weight-loss miracle” is troubling because, as writer Aubrey Gordon said on Slate’s The Waves podcast recently, “when we get this spun up about a weight-loss drug this early, it’s usually a bad sign because it means that people will get more attached to the fantasy of weight loss.” (Also, it’s worth noting, the long-term effects of these drugs are still being studied.)

What these drugs can’t fix is what underlies the “obesity epidemic” — a culture that continues to hate fat people, a health-care system that incentivizes our weight loss over our actual well-being, and a food system that denies us access to whole, healthy foods.

But my body alone can’t remedy all that. Perhaps it was my commitment to body positivity’s insights into the diet industry that made me hesitant to consider a drug that would result in weight loss. Until I realized that body positivity is also about doing what is right for you and your body as you see it. Allowing myself to step away from the externally imposed shame and the sense of impossibility that has come with living in this body and really trying to figure out what is best for myself ended up being the key to truly accepting myself.
Spoken like a true fat girl.... bet she had a jelly doughnut in her left hand as she typed with her right.
 
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