Hollywood Health: Bruce Willis Diagnosed With Frontotemporal Dementia
- Thread starter playahaitian
- Start date
Bruce Willis Diagnosed With Frontotemporal Dementia
By Zoe Guy, a news writer who covers film, TV, music, and celebrities
Bruce Willis. Photo: Tolga Akmen/AFP via Getty Images
Bruce Willis has been diagnosed with frontotemporal dementia, according to an announcement from his family. The seasoned actor retired last year after developing aphasia. His spouse, Emma Heming Willis, and his ex-wife, Demi Moore, posted a photo of Willis to Instagram with a caption sharing the news about his condition. “Our family wanted to start by expressing our deepest gratitude for the incredible outpouring of love, support and wonderful stories we have all received since sharing Bruce’s original diagnosis,” the caption reads. “Since we announced Bruce’s diagnosis of aphasia in spring 2022, Bruce’s condition has progressed and we now have a more specific diagnosis: frontotemporal dementia (known as FTD). Unfortunately, challenges with communication are just one symptom of the disease Bruce faces. While this is painful, it is a relief to finally have a clear diagnosis.” FTD is a condition that affects the frontal and temporal lobes of the brain — areas generally associated with personality, behavior, language, and movement. It is the most common form of dementia for people under 60.
“Bruce always believed in using his voice in the world to help others and to raise awareness about important issues both publicly and privately,” the family said in a full statement. “We know in our hearts that — if he could today — he would want to respond by bringing global attention and a connectedness with those who are also dealing with this debilitating disease and how it impacts so many individuals and their families.”
“Bruce has always found joy in life — and has helped everyone he knows to do the same. It has meant the world to see that sense of care echoed back to him and to all of us,” the statement continues. “We have been so moved by the love you have all shared for our dear husband, father, and friend during this difficult time. Your continued compassion, understanding, and respect will enable us to help Bruce live as full a life as possible.” The message is signed by Heming Willis, Moore, and his children, Rumer, Scout, Tallulah, Mabel, and Evelyn.
By Zoe Guy, a news writer who covers film, TV, music, and celebrities
Bruce Willis. Photo: Tolga Akmen/AFP via Getty Images
Bruce Willis has been diagnosed with frontotemporal dementia, according to an announcement from his family. The seasoned actor retired last year after developing aphasia. His spouse, Emma Heming Willis, and his ex-wife, Demi Moore, posted a photo of Willis to Instagram with a caption sharing the news about his condition. “Our family wanted to start by expressing our deepest gratitude for the incredible outpouring of love, support and wonderful stories we have all received since sharing Bruce’s original diagnosis,” the caption reads. “Since we announced Bruce’s diagnosis of aphasia in spring 2022, Bruce’s condition has progressed and we now have a more specific diagnosis: frontotemporal dementia (known as FTD). Unfortunately, challenges with communication are just one symptom of the disease Bruce faces. While this is painful, it is a relief to finally have a clear diagnosis.” FTD is a condition that affects the frontal and temporal lobes of the brain — areas generally associated with personality, behavior, language, and movement. It is the most common form of dementia for people under 60.
“Bruce always believed in using his voice in the world to help others and to raise awareness about important issues both publicly and privately,” the family said in a full statement. “We know in our hearts that — if he could today — he would want to respond by bringing global attention and a connectedness with those who are also dealing with this debilitating disease and how it impacts so many individuals and their families.”
“Bruce has always found joy in life — and has helped everyone he knows to do the same. It has meant the world to see that sense of care echoed back to him and to all of us,” the statement continues. “We have been so moved by the love you have all shared for our dear husband, father, and friend during this difficult time. Your continued compassion, understanding, and respect will enable us to help Bruce live as full a life as possible.” The message is signed by Heming Willis, Moore, and his children, Rumer, Scout, Tallulah, Mabel, and Evelyn.
Damn
Damn. I hear Bruce cool and approachable
Damn.. my father-in-law was just diagnosed with the same. Can't really understand him anymore but this also comes after he beat throat cancer
maybe thats why he did all those whack ass movies like nicholas cage does
Damn. 
its fuked up if he cant remember any of the work he did.
this is basically the last well really ever see of him. sad ,we grew up with him.
this is basically the last well really ever see of him. sad ,we grew up with him.
I didnt mean it like that fam..I see it's still cold out on these BGOL streets, LOL
Im just saying it makes sense, He was trying to make as much money as he could before he got to this point. Cage has no excuse.
yeah all those movies kept him busyI didnt mean it like that fam..
Im just saying it makes sense, He was trying to make as much money as he could before he got to this point. Cage has no excuse.
gave him a purpose i suppose
Had thought Kilmer still recovering
If I recall correctly, there was an article explaining that he was trying to crank out as much work as possible before he lost his ability to function.
I was thinking the same thing... I think he was trying to take anything he could in his condition. Especially with him not being able to remember lines. Large scale movies, doing repeated retakes is expensive.
I didnt mean it like that fam..
Im just saying it makes sense, He was trying to make as much money as he could before he got to this point. Cage has no excuse.
Nicholas Cage: https://www.thethings.com/why-nicolas-cage-stars-in-bad-movies/
I didnt mean it like that fam..
Im just saying it makes sense, He was trying to make as much money as he could before he got to this point. Cage has no excuse.
Bro the answer to all your questions is always money
Sadly Bruce wanted to make sure his kids and extended family were well taken care of
Cage is in the same boat with bad investments
DeNiro and Pacino did this to create trust funds for their grandchildren.
It actually happens all the time.
DeNiro is alleged to have had some cash issues due to his ex-wife's spending habits which came out during his divorce and may be why he was doing so many movies.
Oh hell yeah that too.
Divorce and grandkids be the main reason some of these older actors take these roles.
Yeah dealing with it with my mom now. It is painful.
Thanks to the BGOL fam' for sharing their experiences re: loved ones.
My dad's got a current friend with the condition, and a close friend down the block who went through it in recent years prior to his passing.
On a reassuring note - I'm glad to see that Bruce has a good support system around him. From what I can tell from photos over the years, he's still on quite good terms with ex Demi and their grown children. They all get along with his current wife & younger children.
At the premiere for the film Stakeout, Willis met actress Demi Moore. They married on November 21, 1987, and had three daughters, including Rumer, who was born in August 1988.[76][77][78][79] Willis and Moore announced their separation on June 24, 1998.[80] They filed for divorce on October 18, 2000,[81] and the divorce was finalized later that day.[82][83] Regarding the divorce, Willis stated, "I felt I had failed as a father and a husband by not being able to make it work." He credited actor Will Smith for helping him cope with the situation.[18] He has maintained a close friendship with both Moore and her subsequent husband, actor Ashton Kutcher, and attended their wedding.[84]
Willis was engaged to actress Brooke Burns until they broke up in 2004 after ten months together.[17] He married model Emma Heming in Turks and Caicos on March 21, 2009;[85] guests included his three daughters, as well as Moore and Kutcher. The ceremony was not legally binding, so the couple wed again in a civil ceremony in Beverly Hills six days later. The couple has two daughters, one born in 2012[86] and another born in 2014.[87]
My dad's got a current friend with the condition, and a close friend down the block who went through it in recent years prior to his passing.
On a reassuring note - I'm glad to see that Bruce has a good support system around him. From what I can tell from photos over the years, he's still on quite good terms with ex Demi and their grown children. They all get along with his current wife & younger children.
At the premiere for the film Stakeout, Willis met actress Demi Moore. They married on November 21, 1987, and had three daughters, including Rumer, who was born in August 1988.[76][77][78][79] Willis and Moore announced their separation on June 24, 1998.[80] They filed for divorce on October 18, 2000,[81] and the divorce was finalized later that day.[82][83] Regarding the divorce, Willis stated, "I felt I had failed as a father and a husband by not being able to make it work." He credited actor Will Smith for helping him cope with the situation.[18] He has maintained a close friendship with both Moore and her subsequent husband, actor Ashton Kutcher, and attended their wedding.[84]
Willis was engaged to actress Brooke Burns until they broke up in 2004 after ten months together.[17] He married model Emma Heming in Turks and Caicos on March 21, 2009;[85] guests included his three daughters, as well as Moore and Kutcher. The ceremony was not legally binding, so the couple wed again in a civil ceremony in Beverly Hills six days later. The couple has two daughters, one born in 2012[86] and another born in 2014.[87]
Bruce Willis' Diagnosis of Aphasia Progresses, Diagnosed with Dementia
Bruce Willis' original diagnosis of aphasia has progressed, according to his family members ... who say the latest word from doctors is that he has frontotemporal dementia.
www.tmz.com
Bruce Willis Diagnosed With Dementia After Retiring Due to Aphasia
Bruce Willis has been diagnosed with dementia, after he retired due to aphasia in 2022.
variety.com
Shieeet. Nick Cage blew through his money. And ended up owing Uncle Sam taxes. He needed every check he could get.I didnt mean it like that fam..
Im just saying it makes sense, He was trying to make as much money as he could before he got to this point. Cage has no excuse.
Sorry to hear this!!..
Man, I wouldn't wish that shit on my worst enemy! My boy's baby mother has that shit, and it's scary as fuck, I told him to check her in a mushroom test trial I believe they were having at Sloan Kettering but he is too much of a square to even look into it, even if it means sitting back and watching her shrivel away into nothing.
HOMEHEALTH NEWS
Promising New Drug for Alzheimer’s Disease Inhibits Amyloid Production
New gamma secretase inhibitor blocks only amyloid production, no other functions.
A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with Alzheimer’s
Alzheimer's disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer's disease, but there are medications that can help ease the symptoms.
Alzheimer’s disease. As published today in the Royal Society of Chemistry’s Chemical Communications, the compound — known as “C1” — uses a novel mechanism to efficiently prevent the enzyme gamma-secretase from producing amyloids.
Amyloid fibrils are largely composed of the peptide Amyloid beta, which is produced when enzymes, including gamma secretase, make cuts to the amyloid precursor protein found in high concentrations the membrane of brain cells. C1 is a covalent gamma-secretase inhibitor that blocks the active site on the precursor protein where gamma-secretase would bind to transform it into amyloids, rather than — as traditional enzyme inhibitors do — blocking the active site on gamma-secretase itself.
“Historically, drug trials for gamma secretase inhibitors failed because traditional enzyme inhibitors have severe side effects. They stopped all of the normal functions of gamma secretase,” said Chunyu Wang, a professor of biological sciences and member of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute. “Our compound binds to the cleavage site of the precursor protein instead of the enzyme itself, which may avoid many problems associated with traditional enzyme inhibitors.”
In 2018, with support from the Warren Alpert Foundation, Wang began screening drugs to identify a compound that targets the amyloid precursor protein substrate, which would block the activity of gamma secretase involved in amyloid production while allowing all other functions. He began the search with “in silico screening,” using computer modeling to test tens of millions of compounds.
C1 was one of several candidates to emerge from that screening. As described in the paper, C1 blocks amyloid production with high efficiency when present at micromolar concentrations, both in test tubes and in cell culture. The research is patent pending.
C1 is a covalent inhibitor, meaning it forms a chemical bond with its target. Wang said that because of their permanent bond, covalent inhibitors are more durable than their non-covalent counterparts. Covalent inhibitors make up about one-third of the drug market, even though they have traditionally been viewed as having a higher risk of causing immune reactivity. In recent years, there is surge in the development of covalent inhibitors, as more highly specific covalent inhibitors showed excellent efficacy towards challenging drug targets.
“With a new approach to tackling the principal pathology of Alzheimer’s disease, Chunyu’s work is generating a fresh roster of drug candidates with enormous promise,” said Deepak Vashishth, the director of CBIS. “His works speaks to the power of the interdisciplinary culture of research at CBIS, and we are pleased with this early result.”
Reference: “Substrate Interaction Inhibits gamma-secretase Production of Amyloid-B peptides” by Jing Zhao,Yuanyuan Xiao, Xinyue Liu, Soohyun Kim, Xianzhong Wu, Marilia Barros, Ran Zhuang, Xuben Hou, Yingkai Zhang, Nikolaos K. Robakis, Yue-Ming Li, Jonathan S. Dordick, Iban Ubarretxena-Belandiahij and Chunyu Wang, 3 February 2020, Chemical Communications.
DOI: 10.1039/C9CC09170J
At Rensselaer, Wang was joined in the research by Jonathan Dordick, Jing Zhao, Yuanyuan Xiao, and Xinyue Liu, with additional collaborators from the Icahn School of Medicine at Mount Sinai, Memorial Sloan Kettering Cancer Center, Shandong University, and New York University
HOMEHEALTH NEWS
Promising New Drug for Alzheimer’s Disease Inhibits Amyloid Production
New gamma secretase inhibitor blocks only amyloid production, no other functions.
A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with Alzheimer’s
Alzheimer's disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer's disease, but there are medications that can help ease the symptoms.
Alzheimer’s disease. As published today in the Royal Society of Chemistry’s Chemical Communications, the compound — known as “C1” — uses a novel mechanism to efficiently prevent the enzyme gamma-secretase from producing amyloids.
Amyloid fibrils are largely composed of the peptide Amyloid beta, which is produced when enzymes, including gamma secretase, make cuts to the amyloid precursor protein found in high concentrations the membrane of brain cells. C1 is a covalent gamma-secretase inhibitor that blocks the active site on the precursor protein where gamma-secretase would bind to transform it into amyloids, rather than — as traditional enzyme inhibitors do — blocking the active site on gamma-secretase itself.
“Historically, drug trials for gamma secretase inhibitors failed because traditional enzyme inhibitors have severe side effects. They stopped all of the normal functions of gamma secretase,” said Chunyu Wang, a professor of biological sciences and member of the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselaer Polytechnic Institute. “Our compound binds to the cleavage site of the precursor protein instead of the enzyme itself, which may avoid many problems associated with traditional enzyme inhibitors.”
In 2018, with support from the Warren Alpert Foundation, Wang began screening drugs to identify a compound that targets the amyloid precursor protein substrate, which would block the activity of gamma secretase involved in amyloid production while allowing all other functions. He began the search with “in silico screening,” using computer modeling to test tens of millions of compounds.
C1 was one of several candidates to emerge from that screening. As described in the paper, C1 blocks amyloid production with high efficiency when present at micromolar concentrations, both in test tubes and in cell culture. The research is patent pending.
C1 is a covalent inhibitor, meaning it forms a chemical bond with its target. Wang said that because of their permanent bond, covalent inhibitors are more durable than their non-covalent counterparts. Covalent inhibitors make up about one-third of the drug market, even though they have traditionally been viewed as having a higher risk of causing immune reactivity. In recent years, there is surge in the development of covalent inhibitors, as more highly specific covalent inhibitors showed excellent efficacy towards challenging drug targets.
“With a new approach to tackling the principal pathology of Alzheimer’s disease, Chunyu’s work is generating a fresh roster of drug candidates with enormous promise,” said Deepak Vashishth, the director of CBIS. “His works speaks to the power of the interdisciplinary culture of research at CBIS, and we are pleased with this early result.”
Reference: “Substrate Interaction Inhibits gamma-secretase Production of Amyloid-B peptides” by Jing Zhao,Yuanyuan Xiao, Xinyue Liu, Soohyun Kim, Xianzhong Wu, Marilia Barros, Ran Zhuang, Xuben Hou, Yingkai Zhang, Nikolaos K. Robakis, Yue-Ming Li, Jonathan S. Dordick, Iban Ubarretxena-Belandiahij and Chunyu Wang, 3 February 2020, Chemical Communications.
DOI: 10.1039/C9CC09170J
At Rensselaer, Wang was joined in the research by Jonathan Dordick, Jing Zhao, Yuanyuan Xiao, and Xinyue Liu, with additional collaborators from the Icahn School of Medicine at Mount Sinai, Memorial Sloan Kettering Cancer Center, Shandong University, and New York University
After Reports Claimed Demi Moore Moved Back In With Bruce Willis And His Family After Aphasia Diagnosis, His Wife Emma Weighed In
Rumors had the Willis blended family partially reunited under one roof, but they have since been debunked.
www.cinemablend.com
Demi Moore Has Reportedly Moved Back In With Bruce Willis And His Wife Emma, In Light Of The Actor's Aphasia Diagnosis
By Mike Reyes
published about 8 hours ago
Rumors have the Willis blended family partially reunited under one roof.
When the 2020 pandemic was at its height, an unexpected quarantine for Demi Moore and Bruce Willis resulted in the two ex-spouses and their respective families living together. Years after that cohabitating situation that saw Moore, Willis and Emma Heming Willis all sharing the same space, it looks like that scenario may be happening yet again. If the rumors are true, Moore has allegedly moved in with Bruce and Emma, following the action movie actor’s recently updated aphasia diagnosis, and for a very good reason.
An unnamed source has claimed that this is all happening in the name of what looks like aiding Emma Heming Willis in caring for Bruce. A report from Radar Online shared these remarks from said source, which explained Demi Moore’s supposed actions in the following context:
As Emma Heming Willis is looking to provide the best care for Bruce Willis and create as many fond memories as possible in his retirement, it sounds like Demi Moore’s motivations are totally aligned with those aims. With her recent interviews discussing the balance of caring for family and self, apparently Emma Heming Willis will have some extra help to better tackle the challenges ahead.
One such obstacle revealed itself earlier this week through reports of paparazzi hollering at Bruce Willis in public, which has left the former action star looking confused. With Demi Moore’s rumored move into the Willis household, it might be more likely to avoid such incidents in public, in accordance with the wishes of Emma Heming Willis’ recent statements. Of course, there’s a chance that these rumors are just that, and until we see an official statement from the family, this story should be treated as mere speculation.
Demi Moore and Bruce Willis’ blended family are used to being seen together, especially in light of Willis and his post-diagnosis life. If this report is true, then that reality is even more reinforced thanks to Moore's alleged move into Willis and Emma Heming Willis’ household. This might help contribute to the love in the house by sharing even more precious moments involving the entire family with the world.
Fans can revisit the best Bruce Willis movies while waiting for such updates. Just as Willis’ family wants to make the most valuable memories in the days to come, we can all seek out our favorite memories from throughout the legendary talent’s career.