It seems like everyone on Shameless got their shit together. Which is how you know shit is about to fall apart.
Here's my prediction how
Last episode showed a stark contrast between Debbie's sensible, yet bland relationship and her parent's crazy, destructive passionate one. She is going to notice this at some point, cheat on Neil, and get kicked out
The stress of Ian losing the love of his life triggers a manic episode. This is bad because he is in the middle of nowhere, (presumably) has no medication, and his entire life savings in his back pocket.
Monica's death somehow exposes to the private school that Liam is not Black. He is expelled because he can no longer help them reach their minority quota.
Monica's death also brings Carl back for the funeral and around people who get him into trouble.
Fiona is about to realize that she is not nearly as investment savvy as she thought. She get's royally screwed on the apartment. At some point her badly overfinanced car gets repossessed and the house comes up for grabs. She moves in with Debbie before Neil kicks them both out
The scam Lip and his friend pulled on the sports betting company gives him an unexpected windfall. By that point he'll be drinking and possibly doing coke with college hipster chicks.
Frank will keep on being Frank. He'll see the hidden crazy inside a square chick and try to turn her into a new Monica