Most plant extracts up to three to four months.. if I have some left after four months,
Ill put them in the fridge, for an additional month..
Smallpox vials found in Usa..what the fuck?
- Thread starter killagram
- Start date
Most plant extracts up to three to four months.. if I have some left after four months,
Ill put them in the fridge, for an additional month..
Bruh, aint that the damn truth!!! But aint nobody listening!! Good reply
Bro - you the only person I know that knows who Gary Null is. My uncle put me on to him years ago...Listen to him literally everyday...
Dude been dropping mad science. You ever hear his stories of helping Bobby Steales in Oakland esp. during the AIDS pandemic? I know we talk about Dr. Sebi alot, but dude has some interesting stories of helping people get that other demon up out of them....
I remember when Dick Gregory died he dedicated a segment of his show to Bro. Gregory for like an entire month.....He was the one that put me on to Ivermectin way before mainstream media was talking about it.....
I actually want to go to one of his retreats. The stories people share of having certain illness or aches/pains and him helping them get rid of it is amazing...
@Mrfreddygoodbud - you familiar with Doctah B Sirius ?
Right on, write on, brotha!!!
Brotha, your so right.. That rotten fuck-face puts the E in evil!!
well to be honest, under situations like this.. Im holidng on to it the stash
as long as I can..
just after three months fridge that bitch...
I once had enchinea drops for over a year, took drops
after every meal before winter, didnt even sniffle once..
of course that was with zinc, vit c, d and e tho...
and I drank a lot of peppermint tea..
Speak of the devil...
Sorry it's not a CNN link
Revealed: Documents Show Bill Gates Has Given $319 Million to Media Outlets
Up until his recent messy divorce, Bill Gates enjoyed something of a free pass in corporate media. Generally presented as a kindly nerd who wants to save the world, the Microsoft co-founder was even unironically christened “Saint Bill” by The Guardian.
While other billionaires’ media empires are relatively well known, the extent to which Gates’s cash underwrites the modern media landscape is not. After sorting through over 30,000 individual grants, MintPress can reveal that the Bill and Melinda Gates Foundation (BMGF) has made over $300 million worth of donations to fund media projects.
Recipients of this cash include many of America’s most important news outlets, including CNN, NBC, NPR, PBS and The Atlantic. Gates also sponsors a myriad of influential foreign organizations, including the BBC, The Guardian, The Financial Times and The Daily Telegraph in the United Kingdom; prominent European newspapers such as Le Monde (France), Der Spiegel (Germany) and El País (Spain); as well as big global broadcasters like Al-Jazeera.
The Gates Foundation money going towards media programs has been split up into a number of sections, presented in descending numerical order, and includes a link to the relevant grant on the organization’s website.
Awards Directly to Media Outlets:
- NPR- $24,663,066
- The Guardian (including TheGuardian.org)- $12,951,391
- Cascade Public Media – $10,895,016
- Public Radio International (PRI.org/TheWorld.org)- $7,719,113
- The Conversation- $6,664,271
- Univision- $5,924,043
- Der Spiegel (Germany)- $5,437,294
- Project Syndicate- $5,280,186
- Education Week – $4,898,240
- WETA- $4,529,400
- NBCUniversal Media- $4,373,500
- Nation Media Group (Kenya) – $4,073,194
- Le Monde (France)- $4,014,512
- Bhekisisa (South Africa) – $3,990,182
- El País – $3,968,184
- BBC- $3,668,657
- CNN- $3,600,000
- KCET- $3,520,703
- Population Communications International (population.org) – $3,500,000
- The Daily Telegraph – $3,446,801
- Chalkbeat – $2,672,491
- The Education Post- $2,639,193
- Rockhopper Productions (U.K.) – $2,480,392
- Corporation for Public Broadcasting – $2,430,949
- UpWorthy – $2,339,023
- Financial Times – $2,309,845
- The 74 Media- $2,275,344
- Texas Tribune- $2,317,163
- Punch (Nigeria) – $2,175,675
- News Deeply – $1,612,122
- The Atlantic- $1,403,453
- Minnesota Public Radio- $1,290,898
- YR Media- $1,125,000
- The New Humanitarian- $1,046,457
- Sheger FM (Ethiopia) – $1,004,600
- Al-Jazeera- $1,000,000
- ProPublica- $1,000,000
- Crosscut Public Media – $810,000
- Grist Magazine- $750,000
- Kurzgesagt – $570,000
- Educational Broadcasting Corp – $506,504
- Classical 98.1 – $500,000
- PBS – $499,997
- Gannett – $499,651
- Mail and Guardian (South Africa)- $492,974
- Inside Higher Ed.- $439,910
- BusinessDay (Nigeria) – $416,900
- Medium.com – $412,000
- Nutopia- $350,000
- Independent Television Broadcasting Inc. – $300,000
- Independent Television Service, Inc. – $300,000
- Caixin Media (China) – $250,000
- Pacific News Service – $225,000
- National Journal – $220,638
- Chronicle of Higher Education – $149,994
- Belle and Wissell, Co. $100,000
- Media Trust – $100,000
- New York Public Radio – $77,290
- KUOW – Puget Sound Public Radio – $5,310
Revealed: Documents Show Bill Gates Has Given $319 Million to Media Outlets
Bill Gates has bankrolled hundreds of media outlets and ventures, including CNN and NPR, to the tune of at least $319 million.www.mintpressnews.com
Right on, brotha!! Great post!!! Ive been posting on this board(4 years) the dangers of the TELEVISION, MEDIA/SOCIAL MEDIA has on the masses around us!!
Not really but I found his twitter page and followed him,
Ill give him a peep..
Thanks!!
Yeah seems like a solid dude. Dick Gregory fucked with him hard so that was all the vetting I needed lol
if you ever listen to the Carl Nelson show he is in there a lot
Yea he is that dude, I remember the medical establishment was going after him, bruh kicked their asses
non stop...
But that Dr Sebi food list... bruh that shit is no joke when you feeling fatigued or imbalanced..
Folks laugh at dr sebi but he basically gave you tools to heal yourself for under 75 dollars a month..
while they paying fuckin thousands of dollars and just taking more and more meds..
for symptoms they never had before..
Naw, but I’m going to assume I need to have him on my radar.
It's funny you say that. There's a book called "We're Not Here to Entertain!" by Kevin Mattson that chronicles the punk movement, mainly in the 80s. Most of the authors from that movement wrote noir novels that predicted all of this.
BGOL loves that cac too kinfolk
they say he's here to save people with his vaccines lol
yepThis diabolical, fake mad scientist will warn people about all the biochemical weapons he is about to fire and and then introduce the fake vaccines to “protect” against it.
The sheep will be in fear and make him and big pharma richer one “Dr.” Gates and company starts deploying their shills AKA the shot pushers to get the masses to put more poison in their bodies.
and there will be a HEAVY contingent of people (especially nBGOL) who will talk bad to you for peeping game and not wanting to play along with that shit!
These muffuckas are out of control.. brah
What... in da FUCK?!?
I'm trying to figure this shit out..and why isn't this shit blasting all over the airways..brah
Cause real news never gets reported anymore.. in fact I find more real info and articles on the net than any local news broadcast or newspaper..that’s why it’s best to find out info through the net and various news outlets in diff states and countries than rely on local news
This shouldn't surprise me. I remember almost freaking out when *THIS* happened back in 2015:
- Colin Powel Alert Summary: Research scientists received Small Pox through mail order from a DNA sequencing lab.
https://www.science.org/content/art...-extinct-poxvirus-100000-using-mail-order-dna
How Canadian researchers reconstituted an extinct poxvirus for $100,000 using mail-order DNA
A study that brought horsepox back to life is triggering a new debate about the risks and power of synthetic biology
Eradicating smallpox, one of the deadliest diseases in history, took humanity decades and cost billions of dollars. Bringing the scourge back would probably take a small scientific team with little specialized knowledge half a year and cost about $100,000.
That's one conclusion from an unusual and as-yet unpublished experiment performed last year by Canadian researchers. A group led by virologist David Evans of the University of Alberta in Edmonton, Canada, says it has synthesized the horsepox virus, a relative of smallpox, from genetic pieces ordered in the mail. Horsepox is not known to harm humans—and like smallpox, researchers believe it no longer exists in nature; nor is it seen as a major agricultural threat. But the technique Evans used could be used to recreate smallpox, a horrific disease that was declared eradicated in 1980. "No question. If it's possible with horsepox, it's possible with smallpox," says virologist Gerd Sutter of Ludwig Maximilians University in Munich, Germany.
Evans hopes the research—most of which was done by research associate Ryan Noyce—will help unravel the origins of a centuries-old smallpox vaccine and lead to new, better vaccines or even cancer therapeutics. Scientifically, the achievement isn't a big surprise. Researchers had assumed it would one day be possible to synthesize poxviruses since virologists assembled the much smaller poliovirus from scratch in 2002. But the new work—like the poliovirus reconstitutions before it—is raising troubling questions about how terrorists or rogue states could use modern biotechnology. Given that backdrop, the study marks "an important milestone, a proof of concept of what can be done with viral synthesis," says bioethicist Nicholas Evans—who's not related to David Evans—of the University of Massachusetts in Lowell.
Bringing back an extinct virus that is related to smallpox, that's a pretty inflammatory situation
- PAUL KEIM, NORTHERN ARIZONA UNIVERSITY
Little-noticed discussion
David Evans acknowledges that the research falls in the category of dual-use research, which could be used for good or bad. "Have I increased the risk by showing how to do this? I don't know," he says. "Maybe yes. But the reality is that the risk was always there."
ADVERTISEMENT
Evans discussed the unpublished work in November 2016 at a meeting of the Advisory Committee on Variola Virus Research at the World Health Organization (WHO) in Geneva, Switzerland. (Variola is the official name of the virus that causes smallpox.) A report from that meeting, posted on WHO's website in May, noted that Evans's effort "did not require exceptional biochemical knowledge or skills, significant funds or significant time." But it did not draw much attention from biosecurity experts or the press.
Also little noticed was a press release issued by Tonix, a pharmaceutical company headquartered in New York City with which Evans has collaborated, which also mentioned the feat. Tonix says it hopes to develop the horsepox virus into a human smallpox vaccine that is safer than existing vaccines, which cause severe side effects in a small minority of people. Evans says it could also serve as a platform for the development of vaccines against other diseases, and he says poxvirus synthesis could also aid in the development of viruses that can kill tumors, his other area of research. "I think we need to be aware of the dual-use issues," Evans says. "But we should be taking advantage of the incredible power of this approach."
The double-stranded variola genome is 30 times bigger than the poliovirus genome, which Eckard Wimmer of State University of New York at Stony Brook assembled from mail-ordered fragments in 2002. Its ends are also linked by structures called terminal hairpins, which are a challenge to recreate. And though simply putting the poliovirus genome into a suitable cell will lead to the production of new virus particles, that trick does not work for poxviruses. That made building variola "far more challenging," says Geoffrey Smith of the University of Cambridge in the United Kingdom, who chairs WHO's variola advisory panel.
The world just needs to accept the fact that you can do this and now we have to figure out what is the best strategy for dealing with that
- DAVID EVANS, UNIVERSITY OF ALBERTA
Evans says he did the experiment in part to end the debate about whether recreating a poxvirus was feasible, he says. "The world just needs to accept the fact that you can do this and now we have to figure out what is the best strategy for dealing with that," he says.
Two rejections
Evans declines to discuss details of his work because, after two rejections, he is about to resubmit a paper about it for publication. But the WHO report says the team purchased overlapping DNA fragments, each about 30,000 base pairs in length, from a company that synthesizes DNA commercially. (The company was Geneart, in Regensburg, Germany, Evans says.) That allowed them to stitch together the 212,000-base-pair horsepox virus genome. Introducing the genome into cells infected with a different type of poxvirus led these cells to start producing infectious horsepox virus particles, a technique first shown to work in a 2002 paper in the Proceedings of the National Academy of Sciences. The virus was then "grown, sequenced and characterized," the report notes, and had the predicted genome sequence.
Evans says Science and Nature Communications both rejected the paper. Caroline Ash, an editor at Science, says the paper wasn't formally submitted to the journal, but that Evans inquired about publication and provided the Tonix press release. "While recognizing the technical achievement, ultimately we have decided that your paper would not offer Science readers a sufficient gain of novel biological knowledge to offset the significant administrative burden the manuscript represents in terms of dual-use research of concern," Ash says she replied to Evans.
Evans says he has run his draft papers by Canadian government officials involved in export and trade as well as the Public Health Agency of Canada and the Canadian Food Inspection Agency, which were "very helpful and provided timely and sensible guidance," he says. "These things potentially fall under export legislation, because technically it could be viewed as instructions for manufacturing a pathogen," he says. To avoid running afoul of international conventions, Evans says he "provided sufficient details so that someone knowledgeable could follow what we did, but not a detailed recipe."
Peter Jahrling, a virologist at the National Institutes of Allergy and Infectious Diseases in Bethesda, Maryland, says the paper should definitely be published. "Not only is it novel," he says. "It is also extremely important."
Regulatory questions
Producing the variola virus in the same fashion would be prohibited under WHO regulations and rules in place in many nations. Labs are not allowed to make more than 20% of the variola genome, and the companies that make and sell DNA fragments have voluntary checks in place to prevent their customers from ordering ingredients for certain pathogens unless they have a valid reason. But controlling every company in the world that produces nucleic acids is impossible, Keim says. "We've recognized for quite a few years that regulating this type of activity is essentially impossible," he says.
Instead, Keim says, there should be an international permit system for researchers who want to recreate a virus no longer found in nature. Current U.S. rules already require federally-funded researchers who plan to do an experiment that "generates or reconstitutes an eradicated or extinct agent" that is on a 15-agent list of dual-use agents to undertake a special review and risk assessment. That U.S. list of regulated agents includes variola, but not horsepox, because it's not considered a dangerous virus itself.
The system in Canada is different, says Gregory Koblentz, a biodefense expert at George Mason University in Fairfax, Virginia, who has been looking into the experiment since noticing the Tonix press release in March. There, the rules say even research that does not involve certain dangerous pathogens, but that could nonetheless generate knowledge that poses a dual-use risk, should be reviewed. "That should have captured the horsepox synthesis," he says. Evans talked to federal agencies in Canada, which was not even required of him, and his university did look at the safety aspect of bringing back an animal pathogen. "But as far as I understand, they did not engage in a systematic review of the broader dual-use implications of synthesizing an orthopox virus," says Koblentz. "I don't think this experiment should have been done."
Nicholas Evans, the bioethicist, thinks that new rules need to be put in place given the state of the science. "Soon with synthetic biology ... we're going to talk about viruses that never existed in nature in the first place," he says. "Someone could create something as lethal as smallpox and as infectious as smallpox without ever creating smallpox." WHO should create an information sharing mechanism obliging any member state to inform the organization when researchers plan to synthesize viruses related to smallpox, he argues.
The genie is out of the lamp
- PETER JAHRLING, NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Now that variola can be synthesized, the decision hardly matters, Jahrling says. "You think it's all tucked away nicely in freezers, but it's not," he says. "The genie is out of the lamp." Evans's work is "a gamechanger for the discussion," confirms Andreas Nitsche of the Robert Koch Institute in Berlin, who attended the WHO meeting where Evans presented his work last fall.
Fears of a return of smallpox—which kills up to one-third of its victims—ran high in the United States after 9/11 and the anthrax letters mailed to U.S. politicians and media figures a few weeks later. The events led the U.S. government to amass big new stockpiles of smallpox vaccine and start a vaccination campaign for so-called first responders. But though a smallpox outbreak would almost certainly create panic and pose an unprecedented test for public health systems, scientists familiar with the disease say an outbreak could probably be contained quite easily because smallpox is not highly infectious and spreads slowly—qualities that made it possible to eradicate it in the first place.
Mysterious origins
Much less is known about horsepox. Pox viruses are known to infect many animals, and horsepox is frequently mentioned in historic accounts, but it seems to have disappeared from nature, possibly because of modern husbandry practices. Scientists at the Plum Island Animal Disease Center in New York published a genome sequence for horsepox in 2006, based on a virus isolated from sick horses in Mongolia 40 years earlier. That virus is still held at CDC; Evans says one reason he decided to synthesize a new virus was that he could not get permission to use the CDC samples for commercial purposes.
Evans says his project has academic value as well: It could help elucidate the early history of smallpox immunization. The vaccine used to eradicate smallpox—the world's oldest vaccine—is itself a living virus named vaccinia; it was first used in 1796 by Edward Jenner, a U.K. doctor. Popular accounts usually have Jenner using cowpox to inoculate people after he noticed that dairymaids appeared to be immune to smallpox. But there are also stories implicating horsepox, and the published horsepox genome looks very similar to some old vaccinia strains, bolstering the hypothesis that the vaccine was derived from horses. (To add another layer of confusion, both horsepox and cowpox may originally have been rodent poxviruses that only occasionally infected livestock.)
Evans hopes to study the function of some horsepox genes by making specific deletions, which could shed light on how the vaccine strain arose. "This is the most successful vaccine in human history, the foundation of modern immunology and microbiology, and yet we don't know where it came from," he says. "There is a huge, interesting academic question here."
Updated, 7/7/2017 at 2:30 p.m.: This story has been updated to includes comments from Gregory Koblentz on Canada's system of regulating and reviewing dual use research.
Man this made me think of my granddad, he was use to take this/put it in his tea whenever he would fill a cold coming on... Knock that shit right out
I take the pills twice every fuckin day of my life... brah
Yessir! Granddad was a G, wealth of knowledge
I forgot all about it until I read this thread... I remember taking it myself and as nasty as that shit taste, the positive effects were proven...
Speak of the devil...
Sorry it's not a CNN link
Revealed: Documents Show Bill Gates Has Given $319 Million to Media Outlets
Up until his recent messy divorce, Bill Gates enjoyed something of a free pass in corporate media. Generally presented as a kindly nerd who wants to save the world, the Microsoft co-founder was even unironically christened “Saint Bill” by The Guardian.
While other billionaires’ media empires are relatively well known, the extent to which Gates’s cash underwrites the modern media landscape is not. After sorting through over 30,000 individual grants, MintPress can reveal that the Bill and Melinda Gates Foundation (BMGF) has made over $300 million worth of donations to fund media projects.
Recipients of this cash include many of America’s most important news outlets, including CNN, NBC, NPR, PBS and The Atlantic. Gates also sponsors a myriad of influential foreign organizations, including the BBC, The Guardian, The Financial Times and The Daily Telegraph in the United Kingdom; prominent European newspapers such as Le Monde (France), Der Spiegel (Germany) and El País (Spain); as well as big global broadcasters like Al-Jazeera.
The Gates Foundation money going towards media programs has been split up into a number of sections, presented in descending numerical order, and includes a link to the relevant grant on the organization’s website.
Awards Directly to Media Outlets:
- NPR- $24,663,066
- The Guardian (including TheGuardian.org)- $12,951,391
- Cascade Public Media – $10,895,016
- Public Radio International (PRI.org/TheWorld.org)- $7,719,113
- The Conversation- $6,664,271
- Univision- $5,924,043
- Der Spiegel (Germany)- $5,437,294
- Project Syndicate- $5,280,186
- Education Week – $4,898,240
- WETA- $4,529,400
- NBCUniversal Media- $4,373,500
- Nation Media Group (Kenya) – $4,073,194
- Le Monde (France)- $4,014,512
- Bhekisisa (South Africa) – $3,990,182
- El País – $3,968,184
- BBC- $3,668,657
- CNN- $3,600,000
- KCET- $3,520,703
- Population Communications International (population.org) – $3,500,000
- The Daily Telegraph – $3,446,801
- Chalkbeat – $2,672,491
- The Education Post- $2,639,193
- Rockhopper Productions (U.K.) – $2,480,392
- Corporation for Public Broadcasting – $2,430,949
- UpWorthy – $2,339,023
- Financial Times – $2,309,845
- The 74 Media- $2,275,344
- Texas Tribune- $2,317,163
- Punch (Nigeria) – $2,175,675
- News Deeply – $1,612,122
- The Atlantic- $1,403,453
- Minnesota Public Radio- $1,290,898
- YR Media- $1,125,000
- The New Humanitarian- $1,046,457
- Sheger FM (Ethiopia) – $1,004,600
- Al-Jazeera- $1,000,000
- ProPublica- $1,000,000
- Crosscut Public Media – $810,000
- Grist Magazine- $750,000
- Kurzgesagt – $570,000
- Educational Broadcasting Corp – $506,504
- Classical 98.1 – $500,000
- PBS – $499,997
- Gannett – $499,651
- Mail and Guardian (South Africa)- $492,974
- Inside Higher Ed.- $439,910
- BusinessDay (Nigeria) – $416,900
- Medium.com – $412,000
- Nutopia- $350,000
- Independent Television Broadcasting Inc. – $300,000
- Independent Television Service, Inc. – $300,000
- Caixin Media (China) – $250,000
- Pacific News Service – $225,000
- National Journal – $220,638
- Chronicle of Higher Education – $149,994
- Belle and Wissell, Co. $100,000
- Media Trust – $100,000
- New York Public Radio – $77,290
- KUOW – Puget Sound Public Radio – $5,310
Revealed: Documents Show Bill Gates Has Given $319 Million to Media Outlets
Bill Gates has bankrolled hundreds of media outlets and ventures, including CNN and NPR, to the tune of at least $319 million.
Bruh, the masses aint listening!! Good azz post,, brotha!!
A very interesting video!!
Damn good vid.
Also didn't know he was paying for narratives on normal TV sitcoms as well. People think it's nothing but is definitely covert subliminal brainwashing.
Aint that the damn truth!! Ive been sharing with the board how these rich folks and the corporation is attacking our subconscious minds!!
The television is the best scientific indoctrination tool ever devised. I wonder why the masses havent figured that out yet??
Like I said in the beginning of this pandemic why is the nig who would be basically be geek squad at Best Buy a person that they taking advice from about viruses and solutions.. he is not qualified in that area to be speaking on the matter
Brotha, I know what your talking about.. I thought the same thing, how is this guy the voice of this virus?? Im shocked how people bow down and listen to this guy just because he's a billionaire!! I guess thats what type of illusion/dream/trance were living in!!!
What they ever say about the smallpox.. brah
Found this:
www.nytimes.com
C.D.C. Says ‘Smallpox’ Vials Found in Lab Did Not Contain Disease-Causing Virus (Published 2021)
In a new statement, the Centers for Disease Control and Prevention said the vials found in a Pennsylvania lab contained vaccinia, the virus used in the smallpox vaccine.
Covid19 was the scrimmage.
The next event will be "the game."
The one after that...will be the "Superbowl (Superbug)."
People already have their Dr. Falsie SPIKE PROTEIN BOOSTER COCKTAILS live inside of them...
Vax on Vax on Vax....what can go wrong?
Like @Mrfreddygoodbud said, step up your alt plan game and GET IT WHILE YOU CAN
This CAC already has plans for you.
These have already been approved by the FDA. Two shots and a pill.
ACAM2000
How does ACAM2000 work?
The vaccine is made from a virus called vaccinia, which is a "pox"-type virus related to smallpox but causes milder disease. ACAM2000 cannot cause smallpox; it does not contain the smallpox virus, but rather the "live" vaccinia virus - not dead virus like many other vaccines. For this reason, attentively caring for the vaccination site is important to prevent the virus from spreading from the vaccination site to other parts of the body, or to other people.
ACAM2000 is administered differently than the typical "shot" associated with most vaccinations. A two-pronged stainless steel (or bifurcated) needle is dipped into the vaccine solution and the skin is pricked several times in the upper arm with a droplet of the vaccine. The virus begins growing at the injection site causing a localized infection or "pock" to form. A red, itchy sore spot at the site of the vaccination within 3-4 days is an indicator that the vaccination was successful; that is, there is "a take." A blister develops at the vaccination site and then dries up forming a scab that falls off in the third week, leaving a small scar. The vaccine stimulates a person's immune system to develop antibodies and cells in the blood and elsewhere that can then help the body fight off a real smallpox infection if exposure to smallpox ever occurs.
TPOXX
For Immediate Release: July 13, 2018
The U.S. Food and Drug Administration today approved TPOXX (tecovirimat), the first drug with an indication for treatment of smallpox. Though the World Health Organization declared smallpox, a contagious and sometimes fatal infectious disease, eradicated in 1980, there have been longstanding concerns that smallpox could be used as a bioweapon.
“To address the risk of bioterrorism, Congress has taken steps to enable the development and approval of countermeasures to thwart pathogens that could be employed as weapons. Today’s approval provides an important milestone in these efforts. This new treatment affords us an additional option should smallpox ever be used as a bioweapon,” said FDA Commissioner Scott Gottlieb, M.D. "This is the first product to be awarded a Material Threat Medical Countermeasure priority review voucher. Today’s action reflects the FDA’s commitment to ensuring that the U.S. is prepared for any public health emergency with timely, safe and effective medical products.”
Prior to its eradication in 1980, variola virus, the virus that causes smallpox, was mainly spread by direct contact between people. Symptoms typically began 10 to 14 days after infection and included fever, exhaustion, headache and backache. A rash initially consisting of small, pink bumps progressed to pus-filled sores before finally crusting over and scarring. Complications of smallpox could include encephalitis (inflammation of the brain), corneal ulcerations (an open sore on the clear, front surface of the eye) and blindness.
TPOXX’s effectiveness against smallpox was established by studies conducted in animals infected with viruses that are closely related to the virus that causes smallpox, and was based on measuring survival at the end of the studies. More animals treated with TPOXX lived compared to the animals treated with placebo. TPOXX was approved under the FDA’s Animal Rule, which allows efficacy findings from adequate and well-controlled animal studies to support an FDA approval when it is not feasible or ethical to conduct efficacy trials in humans.
The safety of TPOXX was evaluated in 359 healthy human volunteers without a smallpox infection. The most frequently reported side effects were headache, nausea and abdominal pain.
The FDA granted this application Fast Track and Priority Review designations. TPOXX also received Orphan Drug designation, which provides incentives to assist and encourage the development of drugs for rare diseases and a Material Threat Medical Countermeasure Priority Review Voucher, which provides additional incentives for certain medical products intended to treat or prevent harm from specific chemical, biological, radiological and nuclear threats.
The FDA granted approval of TPOXX to SIGA Technologies Inc.
FDA approves the first drug with an indication for treatment of smallpox
FDA today approved TPOXX (tecovirimat), the first drug with an indication for treatment of smallpox.
JYNNEOS
JYNNEOS (MVA-BN) Smallpox (Monkeypox) Vaccine Description
Bavarian Nordic JYNNEOS smallpox (Monkeypox) vaccine is based on a live, attenuated vaccinia virus (Modified Vaccinia Ankara, MVA-BN), incapable of replicating in the body, yet still capable of eliciting a potent immune response. The MVA is cultured in Chicken Embryo Fibroblast cells placed in a serum-free medium. It is purified and filtered from the cells using various methods, including benzonase digestion.
JYNNEOS (IMVANEX, IMVAMUNE) was initially Approved in 2019 by the U.S. Food and Drug Administration (FDA) and is indicated for preventing smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection. JYNNEOS is the only FDA-approved non-replicating smallpox vaccine and the only FDA-approved monkeypox vaccine for non-military use.
The vaccine was developed in partnership with the U.S. Government to ensure all adult populations can be protected from smallpox, including people with weakened immune systems or at high risk of adverse reactions to traditional smallpox vaccines based on replicating vaccinia virus strains. Typical severe adverse reactions known for replicating vaccinia virus strains, such as myocarditis, encephalitis, generalized vaccinia, or eczema vaccinatum, were not observed during the clinical development program of JYNNEOS.
JYNNEOS (MVA-BN) Smallpox Mpox Vaccine
JYNNEOS (MVA-BN, IMVANEX, IMVAMUNE) is a smallpox mpox vaccine based on a live, attenuated vaccinia virus.