Yi describes their gender identity as "
queer genderfluid enby".
[19] They use they/them pronouns.
On
Twitter, Yi accused
Marilyn Manson of sexual harassment on the set of
House.
[20]
In 2018,
Amber Tamblyn said of her husband
David Cross, "Basically he was rightfully accused of doing something racist to the comedian Charlyne Yi," following tweets that Yi had posted on the subject in 2017.
[21]
In 2021, they spoke out about their experience with
James Franco, specifically discussing their efforts to quit his 2017 film,
The Disaster Artist, after learning of the sexual misconduct allegations against him. Yi also criticized
Seth Rogen for enabling Franco's behavior and continuing to work with him following the allegations.
[22]