Hunting rifles are for hunting and stalking game animals. I wouldn't used them for home defense, unless that's the only thing I have available. Can you image shooting a .30-06 in a house? Your ears would be toast, and you'd better pray that the round doesn't end up in a neighbor's bedroom.
I'm hesitant on using an AR-15 in the house, because of over-penetration as well. Now if I don't have close neighbors, I'd probably think differently.
I'd rather use a hand gun, 9mm, .38, .380 etc... for home defense. But for me, ideally, I'm rolling with the trusty Mossberg 500. If I'm in the house, that's what I'm grabbing first. If the intruder is outside of the home, then I'm grabbing the AR-15, then the hand gun.
If a person gets hit with .30-06 at close quarters, he may not even know he's been hit for a minute. He'll probably have time to turn around and see his own insides against a wall... unless he's hit in the head.